Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods

The interaction between human serum transferrin (hTf) and three promising organometallic Ru (II)- (η 5 -C 5 H 5 ) derived complexes, that have already shown strong in vitro cytotoxicity towards human cancer cell lines, has been investigated using fluorescence spectroscopic techniques. The results su...

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Bibliographic Details
Published in:Biometals 2021-10, Vol.34 (5), p.1029-1042
Main Authors: Santos, Filipa C., Costa, Paulo J., Garcia, M. Helena, Morais, Tânia S.
Format: Article
Language:English
Subjects:
Binding
Binding sites
Biochemistry
Biomedical and Life Sciences
Breast cancer
Cell Biology
Collision dynamics
Coordination compounds
Cytotoxic agents
Cytotoxicity
Estrogens
Fluorescence
Fluorescence spectroscopy
Hydrophobicity
Life Sciences
Medicine/Public Health
Microbiology
Molecular docking
Ovaries
Pharmacology/Toxicology
Plant Physiology
Plasma
Prostate
Proteins
Spectrum analysis
Toxicity
Transferrin
Transferrins
Tumor cell lines
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Summary:The interaction between human serum transferrin (hTf) and three promising organometallic Ru (II)- (η 5 -C 5 H 5 ) derived complexes, that have already shown strong in vitro cytotoxicity towards human cancer cell lines, has been investigated using fluorescence spectroscopic techniques. The results suggested that the formation of Ru-hTf systems involves a dynamic collision. The binding process occurs spontaneously (ΔG 
ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-021-00325-w