An efficient and general method for the synthesis of stable isotope deuterium labeled phthalate esters

• Published in: Journal of labelled compounds & radiopharmaceuticals 2021-08, Vol.64 (10), p.378-384
• Main Authors: Xu, Zhongjie, Zhao, Cheng, Sun, Wen, Lei, Wen, Hu, Zuming
• Format: Article
• Language: English
• Subjects: Chemistry Techniques, Synthetic - methods; Deuterium; Deuterium - chemistry; deuterium labeled; Esters; Esters - chemistry; Isotopic enrichment; Mass spectrometry; Mass spectroscopy; NMR; Nuclear magnetic resonance; o‐xylene‐D10; Phthalate esters; Phthalates; Phthalic Acids - chemistry; plasticizer; Plasticizers - chemical synthesis; Soil water; synthesis; Xylene
• ISSN: 0362-4803; 1099-1344
• DOI: 10.1002/jlcr.3930

An efficient and general synthetic route of deuterium‐labeled phthalate esters is described with high isotopic enrichment and excellent chemical purities using inexpensive and readily available o‐xylene‐D10 as labeled starting material. The structures and isotope‐abundance were confirmed via 1H NMR and mass spectrometry. These deuterium labeled phthalate esters can be used as analytical reference standards for the detection of plasticizer residues in soil, water, food, plastic products, etc. We have developed an efficient and general synthetic route of deuterium labeled phthalate esters, which were prepared from o‐xylene‐D10 in high isotopic enrichment and excellent chemical purities. The products can be used as analytical reference standards for the detection of plasticizer residues in soil, water, food, etc. The advantages of the method are high isotopic enrichment and chemical purity, facile processing, and low costs.