Eosinophils and helminth infection: protective or pathogenic?

Since the earliest descriptions of this enigmatic cell, eosinophils have been implicated in both protective and pathogenic immune responses to helminth infection. Nevertheless, despite substantial data from in vitro studies, human infections, and animal models, their precise role in helminth infecti...

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Bibliographic Details
Published in:Seminars in immunopathology 2021-06, Vol.43 (3), p.363-381
Main Authors: Mitre, E., Klion, A. D.
Format: Article
Language:English
Subjects:
Animal models
Biomedical and Life Sciences
Biomedicine
Eosinophilia
Immune response
Immunology
Immunoregulation
Infections
Internal Medicine
Leukocytes (eosinophilic)
Review
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Summary:Since the earliest descriptions of this enigmatic cell, eosinophils have been implicated in both protective and pathogenic immune responses to helminth infection. Nevertheless, despite substantial data from in vitro studies, human infections, and animal models, their precise role in helminth infection remains incompletely understood. This is due to a number of factors, including the heterogeneity of the many parasites included in the designation “helminth,” the complexity and redundancy in the host immune response to helminths, and the pleiotropic functions of eosinophils themselves. This review examines the consequences of helminth-associated eosinophilia in the context of protective immunity, pathogenesis, and immunoregulation.
ISSN:1863-2297
1863-2300
DOI:10.1007/s00281-021-00870-z