Genome design of hybrid potato

Reinventing potato from a clonally propagated tetraploid into a seed-propagated diploid, hybrid potato, is an important innovation in agriculture. Due to deleterious mutations, it has remained a challenge to develop highly homozygous inbred lines, a prerequisite to breed hybrid potato. Here, we empl...

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Bibliographic Details
Published in:Cell 2021-07, Vol.184 (15), p.3873-3883.e12
Main Authors: Zhang, Chunzhi, Yang, Zhongmin, Tang, Dié, Zhu, Yanhui, Wang, Pei, Li, Dawei, Zhu, Guangtao, Xiong, Xingyao, Shang, Yi, Li, Canhui, Huang, Sanwen
Format: Article
Language:English
Subjects:
Crosses, Genetic
deleterious mutation
Diploidy
Fertility - genetics
Genes, Plant
Genetic Variation
Genetics, Population
genome design
Genome, Plant
heterosis
Heterozygote
Homozygote
hybrid potato
Hybrid Vigor - genetics
Hybridization, Genetic
Mutation - genetics
Pedigree
Plant Breeding
Principal Component Analysis
Selection, Genetic
Solanum tuberosum - genetics
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Summary:Reinventing potato from a clonally propagated tetraploid into a seed-propagated diploid, hybrid potato, is an important innovation in agriculture. Due to deleterious mutations, it has remained a challenge to develop highly homozygous inbred lines, a prerequisite to breed hybrid potato. Here, we employed genome design to develop a generation of pure and fertile potato lines and thereby the uniform, vigorous F1s. The metrics we applied in genome design included the percentage of genome homozygosity and the number of deleterious mutations in the starting material, the number of segregation distortions in the S1 population, the haplotype information to infer the break of tight linkage between beneficial and deleterious alleles, and the genome complementarity of the parental lines. This study transforms potato breeding from a slow, non-accumulative mode into a fast-iterative one, thereby potentiating a broad spectrum of benefits to farmers and consumers. [Display omitted] •Hybrid potato breeding requires a deep understanding of the potato genome•Genetic analysis facilitates purging of deleterious mutations•Breaking tight linkage of deleterious mutations is required to develop elite lines•Crossing of inbred lines from different lineages generated vigorous F1 hybrids Genome design of the first generation of potato inbred lines with high homozygosity enables the exploitation of heterosis in this tuber crop, and transforms potato breeding from a slow, non-accumulative mode into a fast-iterative one.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2021.06.006