Loading…
The long-term fate of renal and visceral vessel reconstruction after open thoracoabdominal aortic aneurysm repair
AbstractObjectivesIn the ever-advancing era of endovascular thoracoabdominal aneurysm (TAAA) repair, understanding long-term patency of renovisceral reconstructions after open TAAA repair provides important benchmarks. MethodsInstitutional open TAAA repair patient data were queried. Patients dying d...
Saved in:
Published in: | Journal of vascular surgery 2021-12, Vol.74 (6), p.1825-1832 |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c451t-99c38434d0bce84bfbd82272bc43962573593954e9d9510ccb45b4e117116cf43 |
---|---|
cites | cdi_FETCH-LOGICAL-c451t-99c38434d0bce84bfbd82272bc43962573593954e9d9510ccb45b4e117116cf43 |
container_end_page | 1832 |
container_issue | 6 |
container_start_page | 1825 |
container_title | Journal of vascular surgery |
container_volume | 74 |
creator | Mohebali, Jahan, MD, MPH Latz, Christopher A., MD, MPH Cambria, Richard P., MD Patel, Virendra I., MD, MPH Ergul, Emel A., MS Lancaster, R. Todd, MD, MPH Conrad, Mark F., MD, MMSc Clouse, W. Darrin, MD |
description | AbstractObjectivesIn the ever-advancing era of endovascular thoracoabdominal aneurysm (TAAA) repair, understanding long-term patency of renovisceral reconstructions after open TAAA repair provides important benchmarks. MethodsInstitutional open TAAA repair patient data were queried. Patients dying during index admission or with incomplete operative detail were excluded. Visceral and renal reconstructions were categorized as bypass, incorporation into a proximal or distal beveled aortic anastomosis, inclusion button, Carrel patch, or hybrid stent along with endarterectomy/stent adjuncts. Axial imaging or angiography determined long-term patency. Vessel event was defined as new occlusion or reintervention after repair. Overall time-to-event analysis was performed as well as separate analyses for each vessel (celiac, superior mesenteric artery [SMA], right renal, left renal) by reconstruction type utilizing Kaplan-Meier methods. Log-rank testing was employed to compare reconstructive strategies. ResultsOver 28 years, 604 repairs (type I, 106 [18%]; type II, 73 [12%]; type III, 195 [32%]; and type IV, 230 [38%]) were identified. Follow-up (median, 500 days) was available in 410/570 (72%) celiac, 406/573 (71%) SMA, 379/532 (71.2%) right renal, and 370/515 (72%) left renal reconstructions. There were five celiac, one SMA, eight right renal, and 10 left renal events. No type of reconstruction or adjunct was significantly associated with event. Overall 5-year patency of all renal/visceral reconstructions was 94% (95% confidence interval, 90%-96%). Estimated 5-year patency of the celiac, SMA, left renal, and right renal were similar, and were 99%, 100%, 97%, and 96%, respectively ( P = .09). ConclusionsVisceral and renal long-term patency after open TAAA repair is excellent regardless of reconstructive technique. No differences are appreciated even when target vessel disease is addressed at the time of reconstruction. These findings continue to substantiate the effective long-term durability of open TAAA repair and are particularly germane to the ongoing evolution of endovascular strategies. |
doi_str_mv | 10.1016/j.jvs.2021.05.043 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2545595726</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0741521421009186</els_id><sourcerecordid>2545595726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-99c38434d0bce84bfbd82272bc43962573593954e9d9510ccb45b4e117116cf43</originalsourceid><addsrcrecordid>eNp9kcFu1DAURa0K1E4LH8AGeckmwc-xk1hISKiiBakSC8racpwX6pDEU9sZaf4ep1NYsGBlWb7nyu88Qt4AK4FB_X4sx0MsOeNQMlkyUZ2RHTDVFHXL1AuyY42AQnIQF-QyxpExANk25-SiEtCA4HJHHu8fkE5--VkkDDMdTELqBxpwMRM1S08PLloM-XLAGHHKL9YvMYXVJucXaobMUb_HhaYHH4z1puv97J5wH5KzuQXXcIxzRvfGhVfk5WCmiK-fzyvy4-bz_fWX4u7b7dfrT3eFFRJSoZStWlGJnnUWW9ENXd9y3vDOikrVXDaVVJWSAlWvJDBrOyE7gZAHg9oOoroi7069--AfV4xJz9so05T_49eouRRSKtnwOkfhFLXBxxhw0PvgZhOOGpjeTOtRZ9N6M62Z1Nl0Zt4-16_djP1f4o_aHPhwCmAe8uAw6GgdLhZ7lx0m3Xv33_qP_9B2couzZvqFR4yjX0NWHDXoyDXT37dVb5vmwJiCtq5-Azs_pKY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545595726</pqid></control><display><type>article</type><title>The long-term fate of renal and visceral vessel reconstruction after open thoracoabdominal aortic aneurysm repair</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Mohebali, Jahan, MD, MPH ; Latz, Christopher A., MD, MPH ; Cambria, Richard P., MD ; Patel, Virendra I., MD, MPH ; Ergul, Emel A., MS ; Lancaster, R. Todd, MD, MPH ; Conrad, Mark F., MD, MMSc ; Clouse, W. Darrin, MD</creator><creatorcontrib>Mohebali, Jahan, MD, MPH ; Latz, Christopher A., MD, MPH ; Cambria, Richard P., MD ; Patel, Virendra I., MD, MPH ; Ergul, Emel A., MS ; Lancaster, R. Todd, MD, MPH ; Conrad, Mark F., MD, MMSc ; Clouse, W. Darrin, MD</creatorcontrib><description>AbstractObjectivesIn the ever-advancing era of endovascular thoracoabdominal aneurysm (TAAA) repair, understanding long-term patency of renovisceral reconstructions after open TAAA repair provides important benchmarks. MethodsInstitutional open TAAA repair patient data were queried. Patients dying during index admission or with incomplete operative detail were excluded. Visceral and renal reconstructions were categorized as bypass, incorporation into a proximal or distal beveled aortic anastomosis, inclusion button, Carrel patch, or hybrid stent along with endarterectomy/stent adjuncts. Axial imaging or angiography determined long-term patency. Vessel event was defined as new occlusion or reintervention after repair. Overall time-to-event analysis was performed as well as separate analyses for each vessel (celiac, superior mesenteric artery [SMA], right renal, left renal) by reconstruction type utilizing Kaplan-Meier methods. Log-rank testing was employed to compare reconstructive strategies. ResultsOver 28 years, 604 repairs (type I, 106 [18%]; type II, 73 [12%]; type III, 195 [32%]; and type IV, 230 [38%]) were identified. Follow-up (median, 500 days) was available in 410/570 (72%) celiac, 406/573 (71%) SMA, 379/532 (71.2%) right renal, and 370/515 (72%) left renal reconstructions. There were five celiac, one SMA, eight right renal, and 10 left renal events. No type of reconstruction or adjunct was significantly associated with event. Overall 5-year patency of all renal/visceral reconstructions was 94% (95% confidence interval, 90%-96%). Estimated 5-year patency of the celiac, SMA, left renal, and right renal were similar, and were 99%, 100%, 97%, and 96%, respectively ( P = .09). ConclusionsVisceral and renal long-term patency after open TAAA repair is excellent regardless of reconstructive technique. No differences are appreciated even when target vessel disease is addressed at the time of reconstruction. These findings continue to substantiate the effective long-term durability of open TAAA repair and are particularly germane to the ongoing evolution of endovascular strategies.</description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/j.jvs.2021.05.043</identifier><identifier>PMID: 34171425</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aneurysm repair complications ; Aortic Aneurysm, Thoracic - diagnostic imaging ; Aortic Aneurysm, Thoracic - physiopathology ; Aortic Aneurysm, Thoracic - surgery ; Blood Vessel Prosthesis Implantation - adverse effects ; Humans ; Late renovisceral events ; Long-term outcome after TAAA repair ; Postoperative Complications - therapy ; Reconstructive Surgical Procedures - adverse effects ; Reintervention after TAAA repair ; Renal Artery - diagnostic imaging ; Renal Artery - physiopathology ; Renal Artery - surgery ; Retreatment ; Retrospective Studies ; Surgery ; Thoracoabdominal aortic aneurysm repair ; Time Factors ; Treatment Outcome ; Vascular Patency</subject><ispartof>Journal of vascular surgery, 2021-12, Vol.74 (6), p.1825-1832</ispartof><rights>Society for Vascular Surgery</rights><rights>2021 Society for Vascular Surgery</rights><rights>Copyright © 2021 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-99c38434d0bce84bfbd82272bc43962573593954e9d9510ccb45b4e117116cf43</citedby><cites>FETCH-LOGICAL-c451t-99c38434d0bce84bfbd82272bc43962573593954e9d9510ccb45b4e117116cf43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27898,27899</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34171425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohebali, Jahan, MD, MPH</creatorcontrib><creatorcontrib>Latz, Christopher A., MD, MPH</creatorcontrib><creatorcontrib>Cambria, Richard P., MD</creatorcontrib><creatorcontrib>Patel, Virendra I., MD, MPH</creatorcontrib><creatorcontrib>Ergul, Emel A., MS</creatorcontrib><creatorcontrib>Lancaster, R. Todd, MD, MPH</creatorcontrib><creatorcontrib>Conrad, Mark F., MD, MMSc</creatorcontrib><creatorcontrib>Clouse, W. Darrin, MD</creatorcontrib><title>The long-term fate of renal and visceral vessel reconstruction after open thoracoabdominal aortic aneurysm repair</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description>AbstractObjectivesIn the ever-advancing era of endovascular thoracoabdominal aneurysm (TAAA) repair, understanding long-term patency of renovisceral reconstructions after open TAAA repair provides important benchmarks. MethodsInstitutional open TAAA repair patient data were queried. Patients dying during index admission or with incomplete operative detail were excluded. Visceral and renal reconstructions were categorized as bypass, incorporation into a proximal or distal beveled aortic anastomosis, inclusion button, Carrel patch, or hybrid stent along with endarterectomy/stent adjuncts. Axial imaging or angiography determined long-term patency. Vessel event was defined as new occlusion or reintervention after repair. Overall time-to-event analysis was performed as well as separate analyses for each vessel (celiac, superior mesenteric artery [SMA], right renal, left renal) by reconstruction type utilizing Kaplan-Meier methods. Log-rank testing was employed to compare reconstructive strategies. ResultsOver 28 years, 604 repairs (type I, 106 [18%]; type II, 73 [12%]; type III, 195 [32%]; and type IV, 230 [38%]) were identified. Follow-up (median, 500 days) was available in 410/570 (72%) celiac, 406/573 (71%) SMA, 379/532 (71.2%) right renal, and 370/515 (72%) left renal reconstructions. There were five celiac, one SMA, eight right renal, and 10 left renal events. No type of reconstruction or adjunct was significantly associated with event. Overall 5-year patency of all renal/visceral reconstructions was 94% (95% confidence interval, 90%-96%). Estimated 5-year patency of the celiac, SMA, left renal, and right renal were similar, and were 99%, 100%, 97%, and 96%, respectively ( P = .09). ConclusionsVisceral and renal long-term patency after open TAAA repair is excellent regardless of reconstructive technique. No differences are appreciated even when target vessel disease is addressed at the time of reconstruction. These findings continue to substantiate the effective long-term durability of open TAAA repair and are particularly germane to the ongoing evolution of endovascular strategies.</description><subject>Aneurysm repair complications</subject><subject>Aortic Aneurysm, Thoracic - diagnostic imaging</subject><subject>Aortic Aneurysm, Thoracic - physiopathology</subject><subject>Aortic Aneurysm, Thoracic - surgery</subject><subject>Blood Vessel Prosthesis Implantation - adverse effects</subject><subject>Humans</subject><subject>Late renovisceral events</subject><subject>Long-term outcome after TAAA repair</subject><subject>Postoperative Complications - therapy</subject><subject>Reconstructive Surgical Procedures - adverse effects</subject><subject>Reintervention after TAAA repair</subject><subject>Renal Artery - diagnostic imaging</subject><subject>Renal Artery - physiopathology</subject><subject>Renal Artery - surgery</subject><subject>Retreatment</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Thoracoabdominal aortic aneurysm repair</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular Patency</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAURa0K1E4LH8AGeckmwc-xk1hISKiiBakSC8racpwX6pDEU9sZaf4ep1NYsGBlWb7nyu88Qt4AK4FB_X4sx0MsOeNQMlkyUZ2RHTDVFHXL1AuyY42AQnIQF-QyxpExANk25-SiEtCA4HJHHu8fkE5--VkkDDMdTELqBxpwMRM1S08PLloM-XLAGHHKL9YvMYXVJucXaobMUb_HhaYHH4z1puv97J5wH5KzuQXXcIxzRvfGhVfk5WCmiK-fzyvy4-bz_fWX4u7b7dfrT3eFFRJSoZStWlGJnnUWW9ENXd9y3vDOikrVXDaVVJWSAlWvJDBrOyE7gZAHg9oOoroi7069--AfV4xJz9so05T_49eouRRSKtnwOkfhFLXBxxhw0PvgZhOOGpjeTOtRZ9N6M62Z1Nl0Zt4-16_djP1f4o_aHPhwCmAe8uAw6GgdLhZ7lx0m3Xv33_qP_9B2couzZvqFR4yjX0NWHDXoyDXT37dVb5vmwJiCtq5-Azs_pKY</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Mohebali, Jahan, MD, MPH</creator><creator>Latz, Christopher A., MD, MPH</creator><creator>Cambria, Richard P., MD</creator><creator>Patel, Virendra I., MD, MPH</creator><creator>Ergul, Emel A., MS</creator><creator>Lancaster, R. Todd, MD, MPH</creator><creator>Conrad, Mark F., MD, MMSc</creator><creator>Clouse, W. Darrin, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>The long-term fate of renal and visceral vessel reconstruction after open thoracoabdominal aortic aneurysm repair</title><author>Mohebali, Jahan, MD, MPH ; Latz, Christopher A., MD, MPH ; Cambria, Richard P., MD ; Patel, Virendra I., MD, MPH ; Ergul, Emel A., MS ; Lancaster, R. Todd, MD, MPH ; Conrad, Mark F., MD, MMSc ; Clouse, W. Darrin, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-99c38434d0bce84bfbd82272bc43962573593954e9d9510ccb45b4e117116cf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aneurysm repair complications</topic><topic>Aortic Aneurysm, Thoracic - diagnostic imaging</topic><topic>Aortic Aneurysm, Thoracic - physiopathology</topic><topic>Aortic Aneurysm, Thoracic - surgery</topic><topic>Blood Vessel Prosthesis Implantation - adverse effects</topic><topic>Humans</topic><topic>Late renovisceral events</topic><topic>Long-term outcome after TAAA repair</topic><topic>Postoperative Complications - therapy</topic><topic>Reconstructive Surgical Procedures - adverse effects</topic><topic>Reintervention after TAAA repair</topic><topic>Renal Artery - diagnostic imaging</topic><topic>Renal Artery - physiopathology</topic><topic>Renal Artery - surgery</topic><topic>Retreatment</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Thoracoabdominal aortic aneurysm repair</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohebali, Jahan, MD, MPH</creatorcontrib><creatorcontrib>Latz, Christopher A., MD, MPH</creatorcontrib><creatorcontrib>Cambria, Richard P., MD</creatorcontrib><creatorcontrib>Patel, Virendra I., MD, MPH</creatorcontrib><creatorcontrib>Ergul, Emel A., MS</creatorcontrib><creatorcontrib>Lancaster, R. Todd, MD, MPH</creatorcontrib><creatorcontrib>Conrad, Mark F., MD, MMSc</creatorcontrib><creatorcontrib>Clouse, W. Darrin, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohebali, Jahan, MD, MPH</au><au>Latz, Christopher A., MD, MPH</au><au>Cambria, Richard P., MD</au><au>Patel, Virendra I., MD, MPH</au><au>Ergul, Emel A., MS</au><au>Lancaster, R. Todd, MD, MPH</au><au>Conrad, Mark F., MD, MMSc</au><au>Clouse, W. Darrin, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The long-term fate of renal and visceral vessel reconstruction after open thoracoabdominal aortic aneurysm repair</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>74</volume><issue>6</issue><spage>1825</spage><epage>1832</epage><pages>1825-1832</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><abstract>AbstractObjectivesIn the ever-advancing era of endovascular thoracoabdominal aneurysm (TAAA) repair, understanding long-term patency of renovisceral reconstructions after open TAAA repair provides important benchmarks. MethodsInstitutional open TAAA repair patient data were queried. Patients dying during index admission or with incomplete operative detail were excluded. Visceral and renal reconstructions were categorized as bypass, incorporation into a proximal or distal beveled aortic anastomosis, inclusion button, Carrel patch, or hybrid stent along with endarterectomy/stent adjuncts. Axial imaging or angiography determined long-term patency. Vessel event was defined as new occlusion or reintervention after repair. Overall time-to-event analysis was performed as well as separate analyses for each vessel (celiac, superior mesenteric artery [SMA], right renal, left renal) by reconstruction type utilizing Kaplan-Meier methods. Log-rank testing was employed to compare reconstructive strategies. ResultsOver 28 years, 604 repairs (type I, 106 [18%]; type II, 73 [12%]; type III, 195 [32%]; and type IV, 230 [38%]) were identified. Follow-up (median, 500 days) was available in 410/570 (72%) celiac, 406/573 (71%) SMA, 379/532 (71.2%) right renal, and 370/515 (72%) left renal reconstructions. There were five celiac, one SMA, eight right renal, and 10 left renal events. No type of reconstruction or adjunct was significantly associated with event. Overall 5-year patency of all renal/visceral reconstructions was 94% (95% confidence interval, 90%-96%). Estimated 5-year patency of the celiac, SMA, left renal, and right renal were similar, and were 99%, 100%, 97%, and 96%, respectively ( P = .09). ConclusionsVisceral and renal long-term patency after open TAAA repair is excellent regardless of reconstructive technique. No differences are appreciated even when target vessel disease is addressed at the time of reconstruction. These findings continue to substantiate the effective long-term durability of open TAAA repair and are particularly germane to the ongoing evolution of endovascular strategies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34171425</pmid><doi>10.1016/j.jvs.2021.05.043</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0741-5214 |
ispartof | Journal of vascular surgery, 2021-12, Vol.74 (6), p.1825-1832 |
issn | 0741-5214 1097-6809 |
language | eng |
recordid | cdi_proquest_miscellaneous_2545595726 |
source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
subjects | Aneurysm repair complications Aortic Aneurysm, Thoracic - diagnostic imaging Aortic Aneurysm, Thoracic - physiopathology Aortic Aneurysm, Thoracic - surgery Blood Vessel Prosthesis Implantation - adverse effects Humans Late renovisceral events Long-term outcome after TAAA repair Postoperative Complications - therapy Reconstructive Surgical Procedures - adverse effects Reintervention after TAAA repair Renal Artery - diagnostic imaging Renal Artery - physiopathology Renal Artery - surgery Retreatment Retrospective Studies Surgery Thoracoabdominal aortic aneurysm repair Time Factors Treatment Outcome Vascular Patency |
title | The long-term fate of renal and visceral vessel reconstruction after open thoracoabdominal aortic aneurysm repair |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-03-05T02%3A16%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20long-term%20fate%20of%20renal%20and%20visceral%20vessel%20reconstruction%20after%20open%20thoracoabdominal%20aortic%20aneurysm%20repair&rft.jtitle=Journal%20of%20vascular%20surgery&rft.au=Mohebali,%20Jahan,%20MD,%20MPH&rft.date=2021-12-01&rft.volume=74&rft.issue=6&rft.spage=1825&rft.epage=1832&rft.pages=1825-1832&rft.issn=0741-5214&rft.eissn=1097-6809&rft_id=info:doi/10.1016/j.jvs.2021.05.043&rft_dat=%3Cproquest_cross%3E2545595726%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c451t-99c38434d0bce84bfbd82272bc43962573593954e9d9510ccb45b4e117116cf43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2545595726&rft_id=info:pmid/34171425&rfr_iscdi=true |