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Photophobia and disability glare in adult patients with Marfan syndrome: a case–control study
Purpose The aim of the present study was to investigate photophobia and disability glare in adult patients with Marfan syndrome (MFS). Methods In this case–control study, 44 patients with MFS (87 eyes) were compared to 44 controls (88 eyes), who were matched for age and sex. The subjects were asked...
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| Published in: | Acta ophthalmologica (Oxford, England) England), 2022-05, Vol.100 (3), p.337-343 |
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| container_end_page | 343 |
| container_issue | 3 |
| container_start_page | 337 |
| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | Sandvik, Gunhild Falleth Rand‐Hendriksen, Svend Drolsum, Liv Kristianslund, Olav |
| description | Purpose
The aim of the present study was to investigate photophobia and disability glare in adult patients with Marfan syndrome (MFS).
Methods
In this case–control study, 44 patients with MFS (87 eyes) were compared to 44 controls (88 eyes), who were matched for age and sex. The subjects were asked to grade their photophobia and glare using 10‐cm visual analogue scales (VAS), which were marked with ‘never’ at zero and ‘always’ at 10 ‐cm. In addition, disability glare was measured with C‐Quant straylight meter.
Results
The patients with MFS had significantly higher VAS scores than the controls in four out of seven statements related to photophobia and glare. When including cataract, spherical equivalent, iris colour, axial length and corneal curvature, three of the seven statements were still significantly different between the two groups. The mean straylight values were 1.29 ± 0.03 log(s) in the MFS group and 1.01 ± 0.03 log(s) in the control group (p |
| doi_str_mv | 10.1111/aos.14935 |
| format | article |
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The aim of the present study was to investigate photophobia and disability glare in adult patients with Marfan syndrome (MFS).
Methods
In this case–control study, 44 patients with MFS (87 eyes) were compared to 44 controls (88 eyes), who were matched for age and sex. The subjects were asked to grade their photophobia and glare using 10‐cm visual analogue scales (VAS), which were marked with ‘never’ at zero and ‘always’ at 10 ‐cm. In addition, disability glare was measured with C‐Quant straylight meter.
Results
The patients with MFS had significantly higher VAS scores than the controls in four out of seven statements related to photophobia and glare. When including cataract, spherical equivalent, iris colour, axial length and corneal curvature, three of the seven statements were still significantly different between the two groups. The mean straylight values were 1.29 ± 0.03 log(s) in the MFS group and 1.01 ± 0.03 log(s) in the control group (p < 0.001, mixed model). These differences remained significant after adjusting for cataract, spherical equivalent, iris colour, axial length and corneal curvature.
Conclusion
Patients with MFS reported more photophobia and had a higher straylight value than the control group. Awareness of these findings of more photophobia and glare in the MFS patients is important when counselling and treating these patients.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.14935</identifier><identifier>PMID: 34173343</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Case-Control Studies ; Cataract ; Cataracts ; Cornea ; disability glare ; Glare ; Humans ; Iris ; Light ; Marfan syndrome ; Marfan Syndrome - complications ; Marfan Syndrome - diagnosis ; ocular straylight ; Patients ; photophobia ; Photophobia - diagnosis ; Photophobia - etiology ; Scandals ; Scattering, Radiation ; Visual Acuity</subject><ispartof>Acta ophthalmologica (Oxford, England), 2022-05, Vol.100 (3), p.337-343</ispartof><rights>2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3885-d7f19b2c72b5c830c9157fdce4f84845fcf90f5f6360f346196ea3233523a77a3</citedby><cites>FETCH-LOGICAL-c3885-d7f19b2c72b5c830c9157fdce4f84845fcf90f5f6360f346196ea3233523a77a3</cites><orcidid>0000-0001-5351-6834 ; 0000-0003-3390-9811</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34173343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandvik, Gunhild Falleth</creatorcontrib><creatorcontrib>Rand‐Hendriksen, Svend</creatorcontrib><creatorcontrib>Drolsum, Liv</creatorcontrib><creatorcontrib>Kristianslund, Olav</creatorcontrib><title>Photophobia and disability glare in adult patients with Marfan syndrome: a case–control study</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
The aim of the present study was to investigate photophobia and disability glare in adult patients with Marfan syndrome (MFS).
Methods
In this case–control study, 44 patients with MFS (87 eyes) were compared to 44 controls (88 eyes), who were matched for age and sex. The subjects were asked to grade their photophobia and glare using 10‐cm visual analogue scales (VAS), which were marked with ‘never’ at zero and ‘always’ at 10 ‐cm. In addition, disability glare was measured with C‐Quant straylight meter.
Results
The patients with MFS had significantly higher VAS scores than the controls in four out of seven statements related to photophobia and glare. When including cataract, spherical equivalent, iris colour, axial length and corneal curvature, three of the seven statements were still significantly different between the two groups. The mean straylight values were 1.29 ± 0.03 log(s) in the MFS group and 1.01 ± 0.03 log(s) in the control group (p < 0.001, mixed model). These differences remained significant after adjusting for cataract, spherical equivalent, iris colour, axial length and corneal curvature.
Conclusion
Patients with MFS reported more photophobia and had a higher straylight value than the control group. Awareness of these findings of more photophobia and glare in the MFS patients is important when counselling and treating these patients.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cataract</subject><subject>Cataracts</subject><subject>Cornea</subject><subject>disability glare</subject><subject>Glare</subject><subject>Humans</subject><subject>Iris</subject><subject>Light</subject><subject>Marfan syndrome</subject><subject>Marfan Syndrome - complications</subject><subject>Marfan Syndrome - diagnosis</subject><subject>ocular straylight</subject><subject>Patients</subject><subject>photophobia</subject><subject>Photophobia - diagnosis</subject><subject>Photophobia - etiology</subject><subject>Scandals</subject><subject>Scattering, Radiation</subject><subject>Visual Acuity</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKxDAUQIMoPkYX_oAE3OhinObZ1p2IL1AUVHAXbtPEiXSaMUmR7vwH_9AvsTrqQvBu7l0cDpeD0DbJDsgwE_DxgPCSiSW0TnIhxiyXxfLvLR7W0EaMT1kmiZR8Fa0xTnLGOFtH6mbqk59PfeUAQ1vj2kWoXONSjx8bCAa7FkPdNQnPITnTpohfXJriKwgWWhz7tg5-Zg4xYA3RvL--ad-m4BscU1f3m2jFQhPN1vceofvTk7vj8_Hl9dnF8dHlWLOiEOM6t6SsqM5pJXTBMl0SkdtaG24LXnBhtS0zK6xkMrOMS1JKA4wyJiiDPAc2QnsL7zz4587EpGYuatM00BrfRUUFF6IURUEGdPcP-uS70A7fKSp5ScuMUjFQ-wtKBx9jMFbNg5tB6BXJ1Gd1NVRXX9UHdufb2FUzU_-SP5kHYLIAXlxj-v9N6uj6dqH8ALNXjFo</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Sandvik, Gunhild Falleth</creator><creator>Rand‐Hendriksen, Svend</creator><creator>Drolsum, Liv</creator><creator>Kristianslund, Olav</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5351-6834</orcidid><orcidid>https://orcid.org/0000-0003-3390-9811</orcidid></search><sort><creationdate>202205</creationdate><title>Photophobia and disability glare in adult patients with Marfan syndrome: a case–control study</title><author>Sandvik, Gunhild Falleth ; Rand‐Hendriksen, Svend ; Drolsum, Liv ; Kristianslund, Olav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3885-d7f19b2c72b5c830c9157fdce4f84845fcf90f5f6360f346196ea3233523a77a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cataract</topic><topic>Cataracts</topic><topic>Cornea</topic><topic>disability glare</topic><topic>Glare</topic><topic>Humans</topic><topic>Iris</topic><topic>Light</topic><topic>Marfan syndrome</topic><topic>Marfan Syndrome - complications</topic><topic>Marfan Syndrome - diagnosis</topic><topic>ocular straylight</topic><topic>Patients</topic><topic>photophobia</topic><topic>Photophobia - diagnosis</topic><topic>Photophobia - etiology</topic><topic>Scandals</topic><topic>Scattering, Radiation</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandvik, Gunhild Falleth</creatorcontrib><creatorcontrib>Rand‐Hendriksen, Svend</creatorcontrib><creatorcontrib>Drolsum, Liv</creatorcontrib><creatorcontrib>Kristianslund, Olav</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandvik, Gunhild Falleth</au><au>Rand‐Hendriksen, Svend</au><au>Drolsum, Liv</au><au>Kristianslund, Olav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photophobia and disability glare in adult patients with Marfan syndrome: a case–control study</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2022-05</date><risdate>2022</risdate><volume>100</volume><issue>3</issue><spage>337</spage><epage>343</epage><pages>337-343</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
The aim of the present study was to investigate photophobia and disability glare in adult patients with Marfan syndrome (MFS).
Methods
In this case–control study, 44 patients with MFS (87 eyes) were compared to 44 controls (88 eyes), who were matched for age and sex. The subjects were asked to grade their photophobia and glare using 10‐cm visual analogue scales (VAS), which were marked with ‘never’ at zero and ‘always’ at 10 ‐cm. In addition, disability glare was measured with C‐Quant straylight meter.
Results
The patients with MFS had significantly higher VAS scores than the controls in four out of seven statements related to photophobia and glare. When including cataract, spherical equivalent, iris colour, axial length and corneal curvature, three of the seven statements were still significantly different between the two groups. The mean straylight values were 1.29 ± 0.03 log(s) in the MFS group and 1.01 ± 0.03 log(s) in the control group (p < 0.001, mixed model). These differences remained significant after adjusting for cataract, spherical equivalent, iris colour, axial length and corneal curvature.
Conclusion
Patients with MFS reported more photophobia and had a higher straylight value than the control group. Awareness of these findings of more photophobia and glare in the MFS patients is important when counselling and treating these patients.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34173343</pmid><doi>10.1111/aos.14935</doi><tpages>343</tpages><orcidid>https://orcid.org/0000-0001-5351-6834</orcidid><orcidid>https://orcid.org/0000-0003-3390-9811</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta ophthalmologica (Oxford, England), 2022-05, Vol.100 (3), p.337-343 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Case-Control Studies Cataract Cataracts Cornea disability glare Glare Humans Iris Light Marfan syndrome Marfan Syndrome - complications Marfan Syndrome - diagnosis ocular straylight Patients photophobia Photophobia - diagnosis Photophobia - etiology Scandals Scattering, Radiation Visual Acuity |
| title | Photophobia and disability glare in adult patients with Marfan syndrome: a case–control study |
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