Nandrolone decanoate safely combats catabolism in burned patients: A new potential indication after recall

• Published in: Burns 2022-02, Vol.48 (1), p.59-68
• Main Authors: Ali, Yasser Helmy, Ali, Tasnim
• Format: Article
• Language: English
• Subjects: Anabolic Agents - therapeutic use; Anti-catabolic effects; Burns; Burns - drug therapy; Humans; Nandrolone - therapeutic use; Nandrolone D; Nandrolone Decanoate; Nitrogen balance; Prospective Studies; Wound healing
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/j.burns.2021.04.011

•Most of the morbidity and mortality in severe burn injuries are related to the hyper-catabolic state.•Anabolic steroids combat the hyper catabolism in human burns.•Nandrolone decanoate (ND) restored near normal nitrogen balance in burn patients.•ND could be used with longtime safety and efficacy to combat hyper-catabolic impact in burn injury. The hyper-catabolic state is a devastating pathophysiological response to severe injury, infection or burns. Nandrolone decanoate (ND) is a potent anabolic steroid have many clinical indications, but not investigated in burn injuries yet. A prospective randomized control study included 40 burned patients who were treated in Burn unit from burn injuries ranged from 20 to 40%. Both groups are objectively assessed, clinically and laboratory during treatment period till full recovery from burns’ injury. Recall assessment of the drug safety after many years is achieved. ND showed highly significant results supporting its use in combating catabolic insults in burns patient. Both clinical findings and laboratory findings are correlated and highly support the use of ND in burns as new effective and safe long-lasting indication. This study results showed preservation of lean body mass and protein partition, as well as the near normal nitrogen balance in burn patients. Study proposes that nandrolone decanoate could be used in safe and effective way to combat hypercatabolic impact in burn injury.