Value of preoperative gastroscopic carbon nanoparticles labeling in patients undergoing laparoscopic radical gastric cancer surgery

• Published in: Surgical oncology 2021-09, Vol.38, p.101628-101628, Article 101628
• Main Authors: Feng, Yun, Yang, Kui, Sun, Huan-huan, Liu, Ya-ping, Zhang, Dan, Zhao, Yan, Shi, Wen, Lu, Gui-fang, Zhang, Zhi-yong, Jia, Ai, He, Shui-xiang, Li, Hong-xia
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biopsy; Cancer; Cancer surgery; Carbon; Carbon - analysis; Carbon nanoparticles; Endoscopy; Female; Follow-Up Studies; Gastric cancer; Gastrointestinal surgery; Gastroscopy - methods; Hospitals; Humans; Labeling; Laparoscopy; Laparoscopy - methods; Length of stay; Lymph node; Lymph Node Excision; Lymph nodes; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic system; Male; Metastases; Metastasis; Middle Aged; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Operative Time; Patients; Pharmaceuticals; Preoperative Care; Prognosis; Retrospective Studies; Statistical analysis; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Surgeons; Surgery; Surgical outcomes; Tumors
• ISSN: 0960-7404; 1879-3320
• DOI: 10.1016/j.suronc.2021.101628

Lymph node metastasis is crucial for gastric cancer. We aim to explore the value of preoperative gastroscopic carbon nanoparticles labeling in patients undergoing laparoscopic radical gastric cancer surgery. 1199 cases undergoing laparoscopic radical gastric cancer surgery were retrospectively analyzed. 214 cases received preoperative gastroscopic carbon nanoparticles labeling. The number of total lymph nodes detected, positive lymph nodes, N staging, and operation time were analyzed. The patients received carbon nanoparticles labeling had more total lymph nodes detected (27.9 ± 6.5 vs 22.2 ± 4.0; P ＜ 0.001) and shorter operation time (185.9 ± 27.8min vs 218.7 ± 69.2min; P ＜ 0.001) compared with the control group. In addition, preoperative endoscopic carbon nanoparticles labeling improved the diagnosis rate of synchronous multiple gastric cancer (2.8% vs 0.4%; P ＜ 0.001). Preoperative endoscopic carbon nanoparticles tracer labeling is of great value in patients undergoing laparoscopic radical gastric cancer surgery. It shortens the operation time, increases the number of total lymph nodes detected for more accurate pathological TNM staging, and finds some cases of synchronous multiple gastric cancer. •It’s a large sample retrospective clinical study to explore value of preoperative gastroscopic carbon nanoparticles labeling.•It shortens the operation duration, increases the number of total lymph nodes detected for accurate pathological TNM staging.•We find some cases of synchronous multiple gastric cancer during preoperative gastroscopic carbon nanoparticles labeling as well.