Pulmonary Microcirculation during Experimental Pulmonary Thromboembolism under Conditions of Activation and Blockade of Muscarinic Acetylcholine Receptors

Changes in pulmonary microcirculation were studied in isolated perfused rabbit lungs during modelling pulmonary thromboembolism under conditions of acetylcholine infusion against the background of treatment with M1 acetylcholine receptor blocker pirenzepine or blockade of muscarinic acetylcholine re...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021-05, Vol.171 (2), p.198-201
Main Authors: Evlakhov, V. I., Berezina, T. P., Poyassov, I. Z., Ovsyannikov, V. I.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Acetylcholine receptors (muscarinic)
Analysis
Animals
Atropine
Atropine - pharmacology
Biomedical and Life Sciences
Biomedicine
Blood Pressure - drug effects
Cell Biology
Disease Models, Animal
Embolism
Internal Medicine
Laboratory Medicine
Lung - blood supply
Lung - drug effects
Microcirculation - drug effects
Muscarinic Antagonists - pharmacology
Nitroglycerin - pharmacology
Pathology
Pirenzepine
Pulmonary arteries
Pulmonary artery
Pulmonary Circulation - drug effects
Pulmonary Circulation - physiology
Pulmonary embolism
Pulmonary Embolism - pathology
Pulmonary Embolism - physiopathology
Pulmonary embolisms
Rabbits
Receptors, Muscarinic - drug effects
Receptors, Muscarinic - metabolism
Thromboembolism
Vascular Resistance - drug effects
Vascular Resistance - physiology
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Summary:Changes in pulmonary microcirculation were studied in isolated perfused rabbit lungs during modelling pulmonary thromboembolism under conditions of acetylcholine infusion against the background of treatment with M1 acetylcholine receptor blocker pirenzepine or blockade of muscarinic acetylcholine receptors with atropine. In the first case, the increase in pulmonary artery pressure was less pronounced than in case of atropine treatment. In response to pulmonary embolism after acetylcholine infusion against the background of pirenzepine pretreatment, the capillary hydrostatic pressure and postcapillary resistance did not change, while after atropine treatment, these parameters increased. In case of pulmonary embolism after acetylcholine infusion combined with selective blockade of M1 muscarinic acetylcholine receptors, the capillary filtration coefficient increased to a greater extent, than in the control and after blockade of muscarinic acetylcholine receptors.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05194-4