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Vagus nerve ultrasonography in Parkinson's disease: A systematic review and meta-analysis

Vagus nerve (VN) has been suggested as one of the major routes of Parkinson's disease (PD) progression from enteric nervous system to brain. Therefore, the recent studies have investigated the VN structurally, with a focus on the changes in its size in PD patients using high-frequency ultrasono...

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Published in:Autonomic neuroscience 2021-09, Vol.234, p.102835-102835, Article 102835
Main Authors: Abdelnaby, Ramy, Elsayed, Mohamed, Mohamed, Khaled A., Dardeer, Khaled T., Sonbol, Yousef Tarek, ELgenidy, Anas, Barakat, Mahmoud H., Alwerdani, Mariam M., Maier, Andrea
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creator Abdelnaby, Ramy
Elsayed, Mohamed
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Alwerdani, Mariam M.
Maier, Andrea
description Vagus nerve (VN) has been suggested as one of the major routes of Parkinson's disease (PD) progression from enteric nervous system to brain. Therefore, the recent studies have investigated the VN structurally, with a focus on the changes in its size in PD patients using high-frequency ultrasonography. This systematic review and meta-analysis aims to evaluate VN size via ultrasound in PD compared to controls. Totally, five studies were included with a total of 238 participants (128 PD patients and 111 controls). The estimate mean difference in four studies showed that the VN CSA was smaller in PD patients with 0.29 mm2 (95% CI, −0.52 to −0.06) and 0.23 mm2 (95% CI, −0.42 to −0.05) for right and left VNs respectively. The test for overall effect was significant for both measurements (p = 0.01). This review reveals that there is a degree of vagus nerve atrophy in PD which could be detected sonographically with high confidence, thus can be used as a marker for vagus neuronal lesion or neuropathy. Further studies are needed to examine its clinical correlation thoroughly.
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subjects Cross sectional area
Meta-analysis
Parkinson's disease
Sonography
Systematic review
Vagus nerve
title Vagus nerve ultrasonography in Parkinson's disease: A systematic review and meta-analysis
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