Recent innovations in cost-effective polymer and paper hybrid microfluidic devices

Hybrid microfluidic systems that are composed of multiple different types of substrates have been recognized as a versatile and superior platform, which can draw benefits from different substrates while avoiding their limitations. This review article introduces the recent innovations of different ty...

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Bibliographic Details
Published in:Lab on a chip 2021-07, Vol.21 (14), p.2658-2683
Main Authors: Zhou, Wan, Dou, Maowei, Timilsina, Sanjay S, Xu, Feng, Li, XiuJun
Format: Article
Language:English
Subjects:
Biomedical materials
Cell Culture Techniques
Cost-Benefit Analysis
Hybrid systems
Innovations
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques
Microfluidic devices
Microfluidics
Nucleic acids
Polydimethylsiloxane
Polymers
Substrates
System effectiveness
Tissue engineering
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Summary:Hybrid microfluidic systems that are composed of multiple different types of substrates have been recognized as a versatile and superior platform, which can draw benefits from different substrates while avoiding their limitations. This review article introduces the recent innovations of different types of low-cost hybrid microfluidic devices, particularly focusing on cost-effective polymer- and paper-based hybrid microfluidic devices. In this article, the fabrication of these hybrid microfluidic devices is briefly described and summarized. We then highlight various hybrid microfluidic systems, including polydimethylsiloxane (PDMS)-based, thermoplastic-based, paper/polymer hybrid systems, as well as other emerging hybrid systems (such as thread-based). The special benefits of using these hybrid systems have been summarized accordingly. A broad range of biological and biomedical applications using these hybrid microfluidic devices are discussed in detail, including nucleic acid analysis, protein analysis, cellular analysis, 3D cell culture, organ-on-a-chip, and tissue engineering. The perspective trends of hybrid microfluidic systems involving the improvement of fabrication techniques and broader applications are also discussed at the end of the review. This article reviews recent innovations in cost-effective polymer and paper hybrid microfluidic devices and their biological and biomedical applications.
ISSN:1473-0197
1473-0189
1473-0189
DOI:10.1039/d1lc00414j