Recent innovations in cost-effective polymer and paper hybrid microfluidic devices

• Published in: Lab on a chip 2021-07, Vol.21 (14), p.2658-2683
• Main Authors: Zhou, Wan, Dou, Maowei, Timilsina, Sanjay S, Xu, Feng, Li, XiuJun
• Format: Article
• Language: English
• Subjects: Biomedical materials; Cell Culture Techniques; Cost-Benefit Analysis; Hybrid systems; Innovations; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques; Microfluidic devices; Microfluidics; Nucleic acids; Polydimethylsiloxane; Polymers; Substrates; System effectiveness; Tissue engineering
• ISSN: 1473-0197; 1473-0189; 1473-0189
• DOI: 10.1039/d1lc00414j

Hybrid microfluidic systems that are composed of multiple different types of substrates have been recognized as a versatile and superior platform, which can draw benefits from different substrates while avoiding their limitations. This review article introduces the recent innovations of different types of low-cost hybrid microfluidic devices, particularly focusing on cost-effective polymer- and paper-based hybrid microfluidic devices. In this article, the fabrication of these hybrid microfluidic devices is briefly described and summarized. We then highlight various hybrid microfluidic systems, including polydimethylsiloxane (PDMS)-based, thermoplastic-based, paper/polymer hybrid systems, as well as other emerging hybrid systems (such as thread-based). The special benefits of using these hybrid systems have been summarized accordingly. A broad range of biological and biomedical applications using these hybrid microfluidic devices are discussed in detail, including nucleic acid analysis, protein analysis, cellular analysis, 3D cell culture, organ-on-a-chip, and tissue engineering. The perspective trends of hybrid microfluidic systems involving the improvement of fabrication techniques and broader applications are also discussed at the end of the review. This article reviews recent innovations in cost-effective polymer and paper hybrid microfluidic devices and their biological and biomedical applications.