Evidence for the atherogenic index of plasma as a potential biomarker for cardiovascular disease in schizophrenia

Background: Schizophrenia is known to be accompanied with increased cardiovascular mortality, which causes reduced life expectancy. Aim: The aim of the current study was to investigate if atherogenic index of plasma (AIP) could be a good marker in assessing cardiovascular disease (CVD) risk in patie...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2021-09, Vol.35 (9), p.1120-1126
Main Authors: Onen, Sinay, Taymur, Ibrahim
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - administration & dosage
Antipsychotics
Atherosclerosis - blood
Atherosclerosis - epidemiology
Biomarkers
Biomarkers - blood
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Case-Control Studies
Cholesterol
Correlation analysis
Cross-Sectional Studies
Female
Heart Disease Risk Factors
Humans
Life span
Lipids - blood
Male
Mental disorders
Metabolic disorders
Middle Aged
Patients
Schizophrenia
Schizophrenia - complications
Schizophrenia - drug therapy
Young Adult
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Summary:Background: Schizophrenia is known to be accompanied with increased cardiovascular mortality, which causes reduced life expectancy. Aim: The aim of the current study was to investigate if atherogenic index of plasma (AIP) could be a good marker in assessing cardiovascular disease (CVD) risk in patients with schizophrenia. Methods: Patients with schizophrenia (n = 328) and healthy controls (n = 141) were recruited. Schizophrenia patients were evaluated according to the presence of antipsychotic (AP) drug use as AP(+)Sch group and AP(−)Sch group. Atherogenic indices, such as AIP, Castelli’s risk index-I (CRI-I), Castelli’s risk index-II (CRI-II), and atherogenic coefficient (AC), were calculated according to the laboratory examination of serum lipid parameters. Results: According to the comparison of serum lipid levels, triglyceride (TG) levels were found to be highest and high-density lipoprotein–cholesterol levels were lowest in AP(+)Sch group than AP(−)Sch group and control group (CG) (p 
ISSN:0269-8811
1461-7285
DOI:10.1177/02698811211026450