Hyperpolarized 129Xe magnetic resonance spectroscopy in a rat model of bronchopulmonary dysplasia

Premature infants often require mechanical ventilation and oxygen therapy, which can result in bronchopulmonary dysplasia (BPD), characterized by developmental arrest and impaired lung function. Conventional clinical methods for assessing the prenatal lung are not adequate for the detection and asse...

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Published in:American journal of physiology. Lung cellular and molecular physiology 2021-09, Vol.321 (3), p.L507-L517
Main Authors: Fliss, Jordan D, Zanette, Brandon, Friedlander, Yonni, Sadanand, Siddharth, Lindenmaier, Andras A, Stirrat, Elaine, Li, Daniel, Post, Martin, Jankov, Robert P, Santyr, Giles
Format: Article
Language:English
Subjects:
Alveoli
Capillaries
Data acquisition
Dysplasia
Gas exchange
Health risks
Hematocrit
Histology
Infants
Lung diseases
Lungs
Magnetic resonance spectroscopy
Mechanical ventilation
Microstructure
Oxygen
Resonance
Respiratory function
Risk assessment
Rodents
Spectroscopy
Spectrum analysis
Transit time
Xenon
Xenon 129
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Summary:Premature infants often require mechanical ventilation and oxygen therapy, which can result in bronchopulmonary dysplasia (BPD), characterized by developmental arrest and impaired lung function. Conventional clinical methods for assessing the prenatal lung are not adequate for the detection and assessment of long-term health risks in infants with BPD, highlighting the need for a noninvasive tool for the characterization of lung microstructure and function. Theoretical diffusion models, like the model of xenon exchange (MOXE), interrogate alveolar gas exchange by predicting the uptake of inert hyperpolarized (HP) 129Xe gas measured with HP 129Xe magnetic resonance spectroscopy (MRS). To investigate HP 129Xe MRS as a tool for noninvasive characterization of pulmonary microstructural and functional changes in vivo, HP 129Xe gas exchange data were acquired in an oxygen exposure rat model of BPD that recapitulates the fewer and larger distal airways and pulmonary vascular stunting characteristics of BPD. Gas exchange parameters from MOXE, including airspace mean chord length (Lm), apparent hematocrit in the pulmonary capillaries (HCT), and pulmonary capillary transit time (tx), were compared with airspace mean axis length and area density (MAL and ρA) and percentage area of tissue and air (PTA and PAA) from histology. Lm was significantly larger in the exposed rats (P = 0.003) and correlated with MAL, ρA, PTA, and PAA (0.59
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00612.2020