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Human Cancer Cell Membrane-Cloaked Fe3O4 Nanocubes for Homologous Targeting Improvement

Surface modification of nanoparticles with cellular protein components is a new biomimetic modification strategy, which utilizes the inherent affinity between homologous cells to introduce the same surface molecules into nanoparticles to improve the targeting performance. In this study, oleic acid (...

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Published in:The journal of physical chemistry. B 2021-07, Vol.125 (27), p.7417-7426
Main Authors: Zhang, Lichuang, Xu, Hao, Cheng, Ziyi, Wei, Yan, Sun, Ruize, Liang, Ziwei, Hu, Yinchun, Zhao, Liqin, Lian, Xiaojie, Li, Xia, Huang, Di
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container_end_page 7426
container_issue 27
container_start_page 7417
container_title The journal of physical chemistry. B
container_volume 125
creator Zhang, Lichuang
Xu, Hao
Cheng, Ziyi
Wei, Yan
Sun, Ruize
Liang, Ziwei
Hu, Yinchun
Zhao, Liqin
Lian, Xiaojie
Li, Xia
Huang, Di
description Surface modification of nanoparticles with cellular protein components is a new biomimetic modification strategy, which utilizes the inherent affinity between homologous cells to introduce the same surface molecules into nanoparticles to improve the targeting performance. In this study, oleic acid (OA)-coated Fe3O4 nanocubes were prepared by a high-temperature thermal decomposition method and modified by 3, 4-dihydroxyphenylpropionic acid (DHCA); then, HeLa cell membranes were introduced onto the surface of the nanocubes through mixed coextrusion to try to endow them with the targeting function of natural cells. The results show that the prepared Fe3O4 nanocubes have high monodispersity, excellent water solubility, and biocompatibility. Moreover, the Fe3O4 nanocubes encapsulated by cellular protein show an obvious core–shell structure and the specific targeting property to HeLa cells is improved significantly, which is expected to be used in clinical targeted diagnosis and treatment of cancer.
doi_str_mv 10.1021/acs.jpcb.1c04383
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title Human Cancer Cell Membrane-Cloaked Fe3O4 Nanocubes for Homologous Targeting Improvement
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