Transcriptional regulation of T cell metabolism and metabolic control of T cell gene expression

[Display omitted] T cells undergo activation, maturation, and differentiation in which they can substantially transform and restructure. This includes metabolic adaptations which have been well recognized to be specific for T cell subsets. T cell subset-specific metabolism is thought to reflect diff...

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Bibliographic Details
Published in:Current opinion in genetics & development 2021-10, Vol.70, p.83-88
Main Authors: Veliz, Kimberly, Beier, Ulf H
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation
Humans
Protein Processing, Post-Translational
RNA Processing, Post-Transcriptional
Signal Transduction
T-Lymphocytes - metabolism
Transcription Factors - metabolism
Transcription, Genetic
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Summary:[Display omitted] T cells undergo activation, maturation, and differentiation in which they can substantially transform and restructure. This includes metabolic adaptations which have been well recognized to be specific for T cell subsets. T cell subset-specific metabolism is thought to reflect different bioenergetic requirements as well as adaptations to environmental conditions in which the T cells operate. The metabolic changes that occur in T cells are orchestrated by signaling cascades that lead to rapid post-translational changes and through transcription factors which facilitate more long-term adaptations. In addition, metabolites produced within T cells or taken up from the environment can influence gene expression by altering chromatin accessibility or the effectiveness of transcription factors through post-translational modifications, and thus act as transcription regulators in their own right.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2021.06.004