Antimicrobial alkaloids from the root bark of Dictamnus dasycarpus

Two new furoquinoline alkaloids, named 1'-oxo-isoplatydesmine (1) and demethoxyacrophylline (2), as well as 11 known alkaloids (3-13) were isolated from the root bark of Dictamnus dasycarpus Turcz. The structures of 1 and 2 were established by detailed spectroscopic elucidation, such as 1 D &am...

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Bibliographic Details
Published in:Journal of asian natural products research 2022-05, Vol.24 (5), p.483-489
Main Authors: Tian, Meng-Yin, Bao, Jie, Li, Xin, Zhang, Qian-Ru, Li, Sha-Sha, Gan, Mao-Luo, Wang, Su-Juan
Format: Article
Language:English
Subjects:
alkaloid
Alkaloids
Anti-Infective Agents - pharmacology
antimicrobial activity
Dictamnus - chemistry
Dictamnus dasycarpus
furoquinoline
Molecular Structure
Plant Bark - chemistry
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Summary:Two new furoquinoline alkaloids, named 1'-oxo-isoplatydesmine (1) and demethoxyacrophylline (2), as well as 11 known alkaloids (3-13) were isolated from the root bark of Dictamnus dasycarpus Turcz. The structures of 1 and 2 were established by detailed spectroscopic elucidation, such as 1 D & 2 D NMR and HRMS, etc. The unexpected autoracemization of 1 was discussed based on the stereochemistry of reported dihydrofuroquinolines. Compounds 3-5 exhibited moderate inhibitory activities against Bacillus subtilis, Candida albicans, and Pseudomonas aeruginosa with MICs 32-64 μg/ml, revealing the active principles of D. dasycarpus for treating skin diseases in its traditional usage.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2021.1939311