Safety profile of clozapine: Analysis using national registry data in Japan

Clozapine is the only effective antipsychotic drug used for the treatment of treatment-resistant schizophrenia. Although it has been shown that the frequency of clozapine use is very low in Japan, our previous study revealed that the number of clozapine prescriptions has been increasing in recent ye...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychiatric research 2021-09, Vol.141, p.116-123
Main Authors: Imazu, Shinichi, Hata, Takeo, Toyoda, Katsunori, Kubo, Yoichiro, Yamauchi, Shigeru, Kinoshita, Shinya, Nishihara, Masami, Inada, Ken, Kanazawa, Tetsufumi
Format: Article
Language:English
Subjects:
Antipsychotic drug
Cardiac disorder
Clozapine
Neutropenia/leucopenia
Treatment-resistant schizophrenia
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clozapine is the only effective antipsychotic drug used for the treatment of treatment-resistant schizophrenia. Although it has been shown that the frequency of clozapine use is very low in Japan, our previous study revealed that the number of clozapine prescriptions has been increasing in recent years, and that risk factors leading to discontinuation of clozapine were also identified as age ≥40 years, poor tolerability to olanzapine, previous treatment with clozapine, and white blood cell count
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2021.06.041