Classification performance of clinical risk scoring in suspected acute coronary syndrome beyond a rule-out troponin profile

High-sensitivity cardiac troponin strategies can provide risk stratification in patients with suspected acute coronary syndrome (ACS) in the emergency department (ED). This study evaluated whether clinical risk scoring improves the classification performance of a rule-out profile in suspected ACS. P...

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Bibliographic Details
Published in:European heart journal. Acute cardiovascular care 2021-12, Vol.10 (9), p.1038-1047
Main Authors: Khan, Ehsan, Lambrakis, Kristina, Blyth, Andrew, Seshadri, Anil, Edmonds, Michael J R, Briffa, Tom, Cullen, Louise A, Quinn, Stephen, Horsfall, Matthew, Morton, Erin, French, John K, Papendick, Cynthia, Nelson, Adam J, Chew, Derek P
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - diagnosis
Biomarkers
Chest Pain - diagnosis
Chest Pain - etiology
Emergency Service, Hospital
Humans
Myocardial Infarction - diagnosis
Prospective Studies
Risk Assessment
Troponin
Troponin T
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Summary:High-sensitivity cardiac troponin strategies can provide risk stratification in patients with suspected acute coronary syndrome (ACS) in the emergency department (ED). This study evaluated whether clinical risk scoring improves the classification performance of a rule-out profile in suspected ACS. Patients presenting to ED with suspected ACS as part of the RAPID-TnT trial randomized to the intervention arm were included. Results ≥5 ng/L were available for all participants in this analysis. We evaluated the Thrombolysis In Myocardial Infarction (TIMI) risk score, History ECG Age Risk factors Troponin (HEART) score, and Emergency Department Assessment of Chest pain Score (EDACS) in addition to a rule-out profile based on the 0/1-h high-sensitivity cardiac troponin T protocol (
ISSN:2048-8726
2048-8734
DOI:10.1093/ehjacc/zuab040