Quantification of smooth pursuit dysfunction in multiple sclerosis

: Smooth pursuit dysfunction is common in MS, but rarely quantified and may be missed on exam. : NeuroFitONE™ smooth pursuit performance measures were compared between MS (n = 20) and healthy control (n = 19) participants. : Compared to controls, MS patients had lower proportion of smooth pursuit (0...

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Bibliographic Details
Published in:Multiple sclerosis and related disorders 2021-09, Vol.54, p.103073-103073, Article 103073
Main Authors: Rempe, Torge, Dastgheyb, Neda, Miner, Annalise, Palomino, Miryam, Kinkel, Revere, Liston, Dorion, Graves, Jennifer S.
Format: Article
Language:English
Subjects:
Efferent visual system dysfunction
Eye tracker
Saccadic breakdown of smooth pursuit
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Summary:: Smooth pursuit dysfunction is common in MS, but rarely quantified and may be missed on exam. : NeuroFitONE™ smooth pursuit performance measures were compared between MS (n = 20) and healthy control (n = 19) participants. : Compared to controls, MS patients had lower proportion of smooth pursuit (0.63 vs. 0.73; p = 0.047), increased directional (10.1 vs. 8°; p = 0.014) and speed noise (4.3 vs. 3.1°/sec; p = 0.021) and reduced initiation acceleration (96.83 vs. 115.33°/sec2; p = 0.061). Significant univariate correlations with clinical scores (EDSS, T25-FW) were observed. : Smooth pursuit dysfunction in MS can be readily quantified and distinguishes MS eyes from healthy controls.
ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2021.103073