Surgical outcomes for medically refractory epilepsy secondary to posterior cortex ulegyria as sequelae of perinatal insults

• Published in: Epilepsy research 2021-09, Vol.175, p.106703-106703, Article 106703
• Main Authors: Kurwale, Nilesh S., Patil, Sandip B., Jagtap, Sujit A., Joshi, Aniruddha, Deshmukh, Yogeshwari, Nilegaonkar, Sujit, Bapat, Deepa, Chitnis, Sonal, Wadhwani, Nayan
• Format: Article
• Language: English
• Subjects: Cerebral Cortex - diagnostic imaging; Cerebral Cortex - surgery; Child; Child, Preschool; Drug Resistant Epilepsy - diagnostic imaging; Drug Resistant Epilepsy - etiology; Drug Resistant Epilepsy - surgery; Electroencephalography; Epilepsy surgery; Humans; Infant; Magnetic Resonance Imaging; Neonatal hypoglycemic brain injury; Occipital epilepsy; Parieto-occipital gliosis; Posterior cortex epilepsy; Treatment Outcome; Ulegyria
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2021.106703

•Pharmaco-resistant epilepsy is common sequelae of perinatal insults.•Imaging mostly reveals bilateral parieto-occipital gliosis/ulegyria pattern.•Electrophysiology localizes to posterior head region but mostly non-lateralizing.•Despite deterrents, curative intent surgeries lead to excellent seizure outcomes.•Complete corpus callosotomy offers excellent palliation in one third of the cohort. To study surgical outcomes in pharmaco-resistant epilepsy associated with posterior cortex ulegyria secondary to perinatal insults. A cohort was analysed for clinico-radiological charectaristics, surgical interventions and seizure outcomes. A total of 38 patients underwent surgery, divided as group A - curative surgeries (n = 20) and group B - palliative surgeries (n = 18). Mean age of onset of epilepsy in group A was 5.2 ± 3.4 years against 2.7 ± 2.4 years in group B (p