Loading…
Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex
Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic...
Saved in:
Published in: | Journal of applied physiology (1985) 2021-08, Vol.131 (2), p.794-807 |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c318t-61c69d2495ccd5e7e6f9a383242df2aca51be8f056f486395b4cfa6f61f6d0133 |
---|---|
cites | cdi_FETCH-LOGICAL-c318t-61c69d2495ccd5e7e6f9a383242df2aca51be8f056f486395b4cfa6f61f6d0133 |
container_end_page | 807 |
container_issue | 2 |
container_start_page | 794 |
container_title | Journal of applied physiology (1985) |
container_volume | 131 |
creator | Paula-Ribeiro, Marcelle Ribeiro, Indyanara C. Aranda, Liliane C. Silva, Talita M. Costa, Camila M. Ramos, Roberta P. Ota-Arakaki, Jaquelina Cravo, Sergio L. Nery, Luiz E. Stickland, Michael K. Silva, Bruno M. |
description | Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.
The baroreflex integrity in early-stage pulmonary arterial hypertension (PAH) remains uninvestigated. A potential baroreflex impairment could be functionally relevant and possibly mediated by enhanced peripheral chemoreflex activity. Thus, we investigated 1) the cardiac baroreflex in nonhypoxemic PAH; 2) the association between baroreflex indexes and peak aerobic capacity [i.e., peak oxygen consumption (V̇o
2peak
)]; and 3) the peripheral chemoreflex contribution to the cardiac baroreflex. Nineteen patients and 13 age- and sex-matched healthy adults (HA) randomly inhaled either 100% O
2
(peripheral chemoreceptor inhibition) or 21% O
2
(control session) while at rest and during a repeated sit-to-stand maneuver. Beat-by-beat analysis of R-R intervals and systolic blood pressure provided indexes of cardiac baroreflex sensitivity (cBRS) and effectiveness (cBEI). The PAH group had lower cBEI for all sequences (cBEI
ALL
) at rest [means ± SD: PAH = 0.5 ± 0.2 vs. HA = 0.7 ± 0.1 arbitrary units (a.u.), P = 0.02] and lower cBRS
ALL
(PAH = 6.8 ± 7.0 vs. HA = 9.7 ± 5.0 ms·mmHg
−1
, P < 0.01) and cBEI
ALL
(PAH = 0.4 ± 0.2 vs. HA= 0.6 ± 0.1 a.u., P < 0.01) during the sit-to-stand maneuver versus the HA group. The cBEI during the sit-to-stand maneuver was independently correlated to V̇o
2peak
(partial r = 0.45, P < 0.01). Hyperoxia increased cBRS and cBEI similarly in both groups at rest and during the sit-to-stand maneuver. Therefore, cardiac baroreflex dysfunction was observed under spontaneous and, most notably, provoked blood pressure fluctuations in nonhypoxemic PAH, was not influenced by the peripheral chemoreflex, and was associated with lower V̇o
2peak
, suggesting that it could be functionally relevant.
NEW & NOTEWORTHY Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new ev |
doi_str_mv | 10.1152/japplphysiol.00152.2021 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2548417488</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2562577407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c318t-61c69d2495ccd5e7e6f9a383242df2aca51be8f056f486395b4cfa6f61f6d0133</originalsourceid><addsrcrecordid>eNpdkc-OFCEQxonRxHHdZ7ASL156Fmj-jTczUXeTTbzoucPQYDNhAIGOzqPs28q4e9h4qkrxqy9f8SH0juAtIZzeHHXOIS_n6lPYYtxHW4opeYE2vaUDEZi8RBslOR4kV_I1elPrsXOMcbJBD3tdZq8NHHRJxbpg_8B8rm6NpvkUwUfIunkbW4Xfvi2Q13BKUZcz6NJs8TrAcs6297FeFnSDYmsDHWeY1-LjT0ilLam2LmOgtv5aP0JJwUJy0BYLfdvnxZYuZRZ7erLxFr1yOlR7_VSv0I8vn7_vb4f7b1_v9p_uBzMS1QZBjNjNlO24MTO30gq306MaKaOzo9poTg5WOcyFY0qMO35gxmnhBHFixmQcr9CHR91c0q-1W59Ovhobgo42rXWinClGJFOqo-__Q49pLbG765SgXEqGZafkI2VKqrUfM-XiT_3HJoKnS2TT88imf5FNl8jGv2jsksA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2562577407</pqid></control><display><type>article</type><title>Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex</title><source>American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list)</source><source>American Physiological Society Free</source><creator>Paula-Ribeiro, Marcelle ; Ribeiro, Indyanara C. ; Aranda, Liliane C. ; Silva, Talita M. ; Costa, Camila M. ; Ramos, Roberta P. ; Ota-Arakaki, Jaquelina ; Cravo, Sergio L. ; Nery, Luiz E. ; Stickland, Michael K. ; Silva, Bruno M.</creator><creatorcontrib>Paula-Ribeiro, Marcelle ; Ribeiro, Indyanara C. ; Aranda, Liliane C. ; Silva, Talita M. ; Costa, Camila M. ; Ramos, Roberta P. ; Ota-Arakaki, Jaquelina ; Cravo, Sergio L. ; Nery, Luiz E. ; Stickland, Michael K. ; Silva, Bruno M.</creatorcontrib><description>Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.
The baroreflex integrity in early-stage pulmonary arterial hypertension (PAH) remains uninvestigated. A potential baroreflex impairment could be functionally relevant and possibly mediated by enhanced peripheral chemoreflex activity. Thus, we investigated 1) the cardiac baroreflex in nonhypoxemic PAH; 2) the association between baroreflex indexes and peak aerobic capacity [i.e., peak oxygen consumption (V̇o
2peak
)]; and 3) the peripheral chemoreflex contribution to the cardiac baroreflex. Nineteen patients and 13 age- and sex-matched healthy adults (HA) randomly inhaled either 100% O
2
(peripheral chemoreceptor inhibition) or 21% O
2
(control session) while at rest and during a repeated sit-to-stand maneuver. Beat-by-beat analysis of R-R intervals and systolic blood pressure provided indexes of cardiac baroreflex sensitivity (cBRS) and effectiveness (cBEI). The PAH group had lower cBEI for all sequences (cBEI
ALL
) at rest [means ± SD: PAH = 0.5 ± 0.2 vs. HA = 0.7 ± 0.1 arbitrary units (a.u.), P = 0.02] and lower cBRS
ALL
(PAH = 6.8 ± 7.0 vs. HA = 9.7 ± 5.0 ms·mmHg
−1
, P < 0.01) and cBEI
ALL
(PAH = 0.4 ± 0.2 vs. HA= 0.6 ± 0.1 a.u., P < 0.01) during the sit-to-stand maneuver versus the HA group. The cBEI during the sit-to-stand maneuver was independently correlated to V̇o
2peak
(partial r = 0.45, P < 0.01). Hyperoxia increased cBRS and cBEI similarly in both groups at rest and during the sit-to-stand maneuver. Therefore, cardiac baroreflex dysfunction was observed under spontaneous and, most notably, provoked blood pressure fluctuations in nonhypoxemic PAH, was not influenced by the peripheral chemoreflex, and was associated with lower V̇o
2peak
, suggesting that it could be functionally relevant.
NEW & NOTEWORTHY Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00152.2021</identifier><language>eng</language><publisher>Bethesda: American Physiological Society</publisher><subject>Aerobic capacity ; Baroreceptors ; Blood pressure ; Chemoreception (internal) ; Fluctuations ; Hyperoxia ; Hypertension ; Oxygen consumption ; Pulmonary hypertension ; Reflexes</subject><ispartof>Journal of applied physiology (1985), 2021-08, Vol.131 (2), p.794-807</ispartof><rights>Copyright American Physiological Society Aug 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c318t-61c69d2495ccd5e7e6f9a383242df2aca51be8f056f486395b4cfa6f61f6d0133</citedby><cites>FETCH-LOGICAL-c318t-61c69d2495ccd5e7e6f9a383242df2aca51be8f056f486395b4cfa6f61f6d0133</cites><orcidid>0000-0002-9995-0035 ; 0000-0002-5350-7679 ; 0000-0003-0473-3706 ; 0000-0001-6317-3361</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Paula-Ribeiro, Marcelle</creatorcontrib><creatorcontrib>Ribeiro, Indyanara C.</creatorcontrib><creatorcontrib>Aranda, Liliane C.</creatorcontrib><creatorcontrib>Silva, Talita M.</creatorcontrib><creatorcontrib>Costa, Camila M.</creatorcontrib><creatorcontrib>Ramos, Roberta P.</creatorcontrib><creatorcontrib>Ota-Arakaki, Jaquelina</creatorcontrib><creatorcontrib>Cravo, Sergio L.</creatorcontrib><creatorcontrib>Nery, Luiz E.</creatorcontrib><creatorcontrib>Stickland, Michael K.</creatorcontrib><creatorcontrib>Silva, Bruno M.</creatorcontrib><title>Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex</title><title>Journal of applied physiology (1985)</title><description>Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.
The baroreflex integrity in early-stage pulmonary arterial hypertension (PAH) remains uninvestigated. A potential baroreflex impairment could be functionally relevant and possibly mediated by enhanced peripheral chemoreflex activity. Thus, we investigated 1) the cardiac baroreflex in nonhypoxemic PAH; 2) the association between baroreflex indexes and peak aerobic capacity [i.e., peak oxygen consumption (V̇o
2peak
)]; and 3) the peripheral chemoreflex contribution to the cardiac baroreflex. Nineteen patients and 13 age- and sex-matched healthy adults (HA) randomly inhaled either 100% O
2
(peripheral chemoreceptor inhibition) or 21% O
2
(control session) while at rest and during a repeated sit-to-stand maneuver. Beat-by-beat analysis of R-R intervals and systolic blood pressure provided indexes of cardiac baroreflex sensitivity (cBRS) and effectiveness (cBEI). The PAH group had lower cBEI for all sequences (cBEI
ALL
) at rest [means ± SD: PAH = 0.5 ± 0.2 vs. HA = 0.7 ± 0.1 arbitrary units (a.u.), P = 0.02] and lower cBRS
ALL
(PAH = 6.8 ± 7.0 vs. HA = 9.7 ± 5.0 ms·mmHg
−1
, P < 0.01) and cBEI
ALL
(PAH = 0.4 ± 0.2 vs. HA= 0.6 ± 0.1 a.u., P < 0.01) during the sit-to-stand maneuver versus the HA group. The cBEI during the sit-to-stand maneuver was independently correlated to V̇o
2peak
(partial r = 0.45, P < 0.01). Hyperoxia increased cBRS and cBEI similarly in both groups at rest and during the sit-to-stand maneuver. Therefore, cardiac baroreflex dysfunction was observed under spontaneous and, most notably, provoked blood pressure fluctuations in nonhypoxemic PAH, was not influenced by the peripheral chemoreflex, and was associated with lower V̇o
2peak
, suggesting that it could be functionally relevant.
NEW & NOTEWORTHY Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.</description><subject>Aerobic capacity</subject><subject>Baroreceptors</subject><subject>Blood pressure</subject><subject>Chemoreception (internal)</subject><subject>Fluctuations</subject><subject>Hyperoxia</subject><subject>Hypertension</subject><subject>Oxygen consumption</subject><subject>Pulmonary hypertension</subject><subject>Reflexes</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkc-OFCEQxonRxHHdZ7ASL156Fmj-jTczUXeTTbzoucPQYDNhAIGOzqPs28q4e9h4qkrxqy9f8SH0juAtIZzeHHXOIS_n6lPYYtxHW4opeYE2vaUDEZi8RBslOR4kV_I1elPrsXOMcbJBD3tdZq8NHHRJxbpg_8B8rm6NpvkUwUfIunkbW4Xfvi2Q13BKUZcz6NJs8TrAcs6297FeFnSDYmsDHWeY1-LjT0ilLam2LmOgtv5aP0JJwUJy0BYLfdvnxZYuZRZ7erLxFr1yOlR7_VSv0I8vn7_vb4f7b1_v9p_uBzMS1QZBjNjNlO24MTO30gq306MaKaOzo9poTg5WOcyFY0qMO35gxmnhBHFixmQcr9CHR91c0q-1W59Ovhobgo42rXWinClGJFOqo-__Q49pLbG765SgXEqGZafkI2VKqrUfM-XiT_3HJoKnS2TT88imf5FNl8jGv2jsksA</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Paula-Ribeiro, Marcelle</creator><creator>Ribeiro, Indyanara C.</creator><creator>Aranda, Liliane C.</creator><creator>Silva, Talita M.</creator><creator>Costa, Camila M.</creator><creator>Ramos, Roberta P.</creator><creator>Ota-Arakaki, Jaquelina</creator><creator>Cravo, Sergio L.</creator><creator>Nery, Luiz E.</creator><creator>Stickland, Michael K.</creator><creator>Silva, Bruno M.</creator><general>American Physiological Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9995-0035</orcidid><orcidid>https://orcid.org/0000-0002-5350-7679</orcidid><orcidid>https://orcid.org/0000-0003-0473-3706</orcidid><orcidid>https://orcid.org/0000-0001-6317-3361</orcidid></search><sort><creationdate>20210801</creationdate><title>Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex</title><author>Paula-Ribeiro, Marcelle ; Ribeiro, Indyanara C. ; Aranda, Liliane C. ; Silva, Talita M. ; Costa, Camila M. ; Ramos, Roberta P. ; Ota-Arakaki, Jaquelina ; Cravo, Sergio L. ; Nery, Luiz E. ; Stickland, Michael K. ; Silva, Bruno M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-61c69d2495ccd5e7e6f9a383242df2aca51be8f056f486395b4cfa6f61f6d0133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aerobic capacity</topic><topic>Baroreceptors</topic><topic>Blood pressure</topic><topic>Chemoreception (internal)</topic><topic>Fluctuations</topic><topic>Hyperoxia</topic><topic>Hypertension</topic><topic>Oxygen consumption</topic><topic>Pulmonary hypertension</topic><topic>Reflexes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paula-Ribeiro, Marcelle</creatorcontrib><creatorcontrib>Ribeiro, Indyanara C.</creatorcontrib><creatorcontrib>Aranda, Liliane C.</creatorcontrib><creatorcontrib>Silva, Talita M.</creatorcontrib><creatorcontrib>Costa, Camila M.</creatorcontrib><creatorcontrib>Ramos, Roberta P.</creatorcontrib><creatorcontrib>Ota-Arakaki, Jaquelina</creatorcontrib><creatorcontrib>Cravo, Sergio L.</creatorcontrib><creatorcontrib>Nery, Luiz E.</creatorcontrib><creatorcontrib>Stickland, Michael K.</creatorcontrib><creatorcontrib>Silva, Bruno M.</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paula-Ribeiro, Marcelle</au><au>Ribeiro, Indyanara C.</au><au>Aranda, Liliane C.</au><au>Silva, Talita M.</au><au>Costa, Camila M.</au><au>Ramos, Roberta P.</au><au>Ota-Arakaki, Jaquelina</au><au>Cravo, Sergio L.</au><au>Nery, Luiz E.</au><au>Stickland, Michael K.</au><au>Silva, Bruno M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex</atitle><jtitle>Journal of applied physiology (1985)</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>131</volume><issue>2</issue><spage>794</spage><epage>807</epage><pages>794-807</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.
The baroreflex integrity in early-stage pulmonary arterial hypertension (PAH) remains uninvestigated. A potential baroreflex impairment could be functionally relevant and possibly mediated by enhanced peripheral chemoreflex activity. Thus, we investigated 1) the cardiac baroreflex in nonhypoxemic PAH; 2) the association between baroreflex indexes and peak aerobic capacity [i.e., peak oxygen consumption (V̇o
2peak
)]; and 3) the peripheral chemoreflex contribution to the cardiac baroreflex. Nineteen patients and 13 age- and sex-matched healthy adults (HA) randomly inhaled either 100% O
2
(peripheral chemoreceptor inhibition) or 21% O
2
(control session) while at rest and during a repeated sit-to-stand maneuver. Beat-by-beat analysis of R-R intervals and systolic blood pressure provided indexes of cardiac baroreflex sensitivity (cBRS) and effectiveness (cBEI). The PAH group had lower cBEI for all sequences (cBEI
ALL
) at rest [means ± SD: PAH = 0.5 ± 0.2 vs. HA = 0.7 ± 0.1 arbitrary units (a.u.), P = 0.02] and lower cBRS
ALL
(PAH = 6.8 ± 7.0 vs. HA = 9.7 ± 5.0 ms·mmHg
−1
, P < 0.01) and cBEI
ALL
(PAH = 0.4 ± 0.2 vs. HA= 0.6 ± 0.1 a.u., P < 0.01) during the sit-to-stand maneuver versus the HA group. The cBEI during the sit-to-stand maneuver was independently correlated to V̇o
2peak
(partial r = 0.45, P < 0.01). Hyperoxia increased cBRS and cBEI similarly in both groups at rest and during the sit-to-stand maneuver. Therefore, cardiac baroreflex dysfunction was observed under spontaneous and, most notably, provoked blood pressure fluctuations in nonhypoxemic PAH, was not influenced by the peripheral chemoreflex, and was associated with lower V̇o
2peak
, suggesting that it could be functionally relevant.
NEW & NOTEWORTHY Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.</abstract><cop>Bethesda</cop><pub>American Physiological Society</pub><doi>10.1152/japplphysiol.00152.2021</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-9995-0035</orcidid><orcidid>https://orcid.org/0000-0002-5350-7679</orcidid><orcidid>https://orcid.org/0000-0003-0473-3706</orcidid><orcidid>https://orcid.org/0000-0001-6317-3361</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 8750-7587 |
ispartof | Journal of applied physiology (1985), 2021-08, Vol.131 (2), p.794-807 |
issn | 8750-7587 1522-1601 |
language | eng |
recordid | cdi_proquest_miscellaneous_2548417488 |
source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
subjects | Aerobic capacity Baroreceptors Blood pressure Chemoreception (internal) Fluctuations Hyperoxia Hypertension Oxygen consumption Pulmonary hypertension Reflexes |
title | Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A33%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiac%20baroreflex%20dysfunction%20in%20patients%20with%20pulmonary%20arterial%20hypertension%20at%20rest%20and%20during%20orthostatic%20stress:%20role%20of%20the%20peripheral%20chemoreflex&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=Paula-Ribeiro,%20Marcelle&rft.date=2021-08-01&rft.volume=131&rft.issue=2&rft.spage=794&rft.epage=807&rft.pages=794-807&rft.issn=8750-7587&rft.eissn=1522-1601&rft_id=info:doi/10.1152/japplphysiol.00152.2021&rft_dat=%3Cproquest_cross%3E2562577407%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c318t-61c69d2495ccd5e7e6f9a383242df2aca51be8f056f486395b4cfa6f61f6d0133%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2562577407&rft_id=info:pmid/&rfr_iscdi=true |