Invasive pneumococcal disease in children under 60 months before and after availability of 13-valent conjugate vaccine

Invasive pneumococcal disease (IPD) is the most important bacterial infection in young children, and the introduction of pneumococcal conjugate vaccines has changed its presentation. This study compared the incidence, characteristics and serotype distribution of IPD before and after the introduction...

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Published in:Anales de Pediatría 2021-06
Main Authors: Martínez-Osorio, Johanna, García-García, Juan José, Moraga-Llop, Fernando, Díaz, Alvaro, Hernández, Sergi, Solé-Ribalta, Anna, González-Peris, Sebastià, Izquierdo, Conchita, Esteva, Cristina, Codina, Gemma, Planes, Ana María, Uriona, Sonia, Campins, Magda, Ciruela, Pilar, Salleras, Luis, Domínguez, Ángela, Muñoz-Almagro, Carmen, de Sevilla, Mariona F
Format: Article
Language:Spanish
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Summary:Invasive pneumococcal disease (IPD) is the most important bacterial infection in young children, and the introduction of pneumococcal conjugate vaccines has changed its presentation. This study compared the incidence, characteristics and serotype distribution of IPD before and after the introduction of the pneumococcal conjugate vaccine (PCV13). Prospective enrolment of patients with IPD aged less than 60 months and admitted to either of 2 tertiary care hospitals between January 2007 and December 2009 (pre-PCV13 period) and January 2012 and June-2016 (PCV13 period). We identified 493 cases, 319 in the pre-PCV13 period and 174 in the PCV13 period. The incidence of IPD decreased from 89.7 to 34.4 cases per 100,000 population (-62%; P
ISSN:2341-2879
DOI:10.1016/j.anpedi.2021.05.018