Factors influencing treatment decision and guideline conformity in high-grade endometrial cancer patients: a population-based study

Purpose Treatment according to guidelines has been demonstrated to improve survival in a number of different cancer entities. Deviations from guidelines depend on several factors, including the patient’s preferences, age and comorbidities. The aim of this study was to assess the adherence to guideli...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2022, Vol.305 (1), p.203-213
Main Authors: Scharl, Sophia, Sprötge, Tim, Gerken, Michael, Scharl, Anton, Ignatov, Atanas, Inwald, Elisabeth C., Ortmann, Olaf, Kölbl, Oliver, Klinkhammer‑Schalke, Monika, Papathemelis, Thomas
Format: Article
Language:English
Subjects:
Adaptation
Cancer surgery
Cancer therapies
Carcinosarcoma - pathology
Chemotherapy
Comorbidity
Conformity
Endocrinology
Endometrial cancer
Endometrial Neoplasms - pathology
Female
Gynecologic Oncology
Gynecology
Human Genetics
Humans
Hysterectomy
Medicine
Medicine & Public Health
Neoplasm Staging
Obstetrics
Obstetrics/Perinatology/Midwifery
Oncology
Patients
Population-based studies
Radiation therapy
Radiotherapy, Adjuvant
Retrospective Studies
Tumors
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Summary:Purpose Treatment according to guidelines has been demonstrated to improve survival in a number of different cancer entities. Deviations from guidelines depend on several factors, including the patient’s preferences, age and comorbidities. The aim of this study was to assess the adherence to guideline recommendations concerning surgical and adjuvant treatment in endometrial cancer. Furthermore, we sought to evaluate the reasons for non-adherence to guidelines by further examining the influence of comorbidities and age. Methods The influence of age, comorbidities, tumor stage and histological subtype on guideline adherence was evaluated by multivariable logistic regression in a cohort of 353 high-grade endometrial cancer patients. High-grade endometrial cancer was defined as carcinosarcoma, Type II (serous, clear cell, mixed cell carcinoma) and Type I G3 histology. Results Extensive surgical procedures, particularly systematic LNE, were less frequently applied in patients with comorbidities ( p  = 0.015) or higher age ( p  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-021-06140-5