Pretreatment Absolute Lymphocyte Count and Neutrophil-to-lymphocyte Ratio Are Prognostic Factors for Stage III Breast Cancer

Background/Aim: Stage III breast cancer comprises a broad spectrum of disease, including the extent of supraclavicular/internal mammary lymph node metastasis. In this study, we evaluated the usefulness of the absolute lymphocyte count (ALC) and neutrophil-to-lymphocyte ratio (NLR) in predicting the...

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Bibliographic Details
Published in:Anticancer research 2021-07, Vol.41 (7), p.3625-3634
Main Authors: Yamanouchi, Kosho, Maeda, Shigeto, Takei, Daiki, Koga, Yoichi, Yamashita, Manpei, Hamada, Takashi, Hirayama, Takanori, Yoneda, Akira, Tokunaga, Takayuki, Takeshita, Hiroaki, Kuroki, Tamotsu
Format: Article
Language:English
Subjects:
Breast cancer
Cell number
Clavicle
Leukocytes (neutrophilic)
Lymph nodes
Lymphatic system
Lymphocytes
Medical prognosis
Metastases
Metastasis
Neutrophils
Patients
Pretreatment
Prognosis
Surgery
Survival
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Summary:Background/Aim: Stage III breast cancer comprises a broad spectrum of disease, including the extent of supraclavicular/internal mammary lymph node metastasis. In this study, we evaluated the usefulness of the absolute lymphocyte count (ALC) and neutrophil-to-lymphocyte ratio (NLR) in predicting the prognosis of patients with stage III breast cancer. Patients and Methods: Seventy-five patients with stage III breast cancer who underwent surgery were included. We compared their clinicopathological factors according to the presence or not of supraclavicular/internal mammary lymph node metastasis, and pretreatment ALC or NLR. Results: Patients with metastasis of the studied lymph nodes had a poorer prognosis in comparison to those without metastasis. In patients without these types of lymph node metastasis, both the ALC and NLR were predictive factors for relapse-free and overall survival. Among these patients, those with a low ALC or high NLR had recurrence-free and overall survival comparable to those of patients with supraclavicular/internal mammary lymph node metastasis. Conclusion: Pretreatment ALC and NLR were prognostic factors for patients with stage III breast cancer.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15151