Effect of Portal Vein and Hepatic Artery Occlusion on Radiofrequency Ablation: Animal Experiment Comparing MR and Histology Measurements of the Ablation Zones

Purpose This animal experimental study evaluated how hepatic artery and portal vein transient occlusion affects the ablation zone of hepatic radiofrequency ablation (RFA). Material and methods Twenty-one rabbits were divided into three groups of seven each: (1) control, (2) hepatic artery occlusion,...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2021-11, Vol.44 (11), p.1790-1797
Main Authors: Inoue, Akitoshi, Nitta, Norihisa, Imai, Yugo, Takaki, Kai, Takahashi, Hiroaki, Ota, Shinichi, Mukaisho, Ken-ichi, Watanabe, Yoshiyuki
Format: Article
Language:English
Subjects:
Ablation
Animal research
Balloon catheters
Cardiology
Catheters
Coagulation
Hepatic artery
Histology
Histopathology
Imaging
Laboratory Investigation
Liver
Liver cancer
Medical instruments
Medicine
Medicine & Public Health
Necrosis
Non-Vascular Interventions
Nuclear Medicine
Occlusion
Portal vein
Rabbits
Radio frequency
Radiofrequency ablation
Radiology
Ultrasound
Veins & arteries
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Summary:Purpose This animal experimental study evaluated how hepatic artery and portal vein transient occlusion affects the ablation zone of hepatic radiofrequency ablation (RFA). Material and methods Twenty-one rabbits were divided into three groups of seven each: (1) control, (2) hepatic artery occlusion, and (3) portal vein occlusion by a balloon catheter. For each rabbit, two or three RFA sessions were performed using an electrode needle. Ablation time, temperature around the tip of RFA needle at the end of RFA, ablation volume on fat-suppressed T1-weighted image in the hepatobiliary phase, and coagulative necrosis area on histopathology were measured and compared between the three groups using the Kruskal–Wallis paired Mann–Whitney U tests. Results In 43 RFA sessions (group 1, 15; group 2, 14; group 3, 14), mean tissue temperature in group 3 (77.0 °C ± 7.7 °C) was significantly higher compared to groups 1 (59.2 °C ± 18.8 °C; P  = 0.010) and 2 (67.5 °C ± 9.9 °C; P  = 0.010). In addition, mean ablation volume and coagulative necrosis in group 3 (2.10 ± 1.37 mm 3 and 0.86 ± 0.28 mm 2 , respectively) were larger compared to groups 1 (0.84 ± 0.30 mm 3 ; P  
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-021-02822-4