Post‐ESWL and post‐ERCP pancreatitis in patients with chronic pancreatitis: Do they share the same risks?

• Published in: Journal of hepato-biliary-pancreatic sciences 2021-09, Vol.28 (9), p.778-787
• Main Authors: Ru, Nan, Qian, Yang‐Yang, Zhu, Jia‐Hui, Chen, Hui, Zou, Wen‐Bin, Hu, Liang‐Hao, Pan, Jun, Guo, Ji‐Yao, Li, Zhao‐Shen, Liao, Zhuan
• Format: Article
• Language: English
• Subjects: calculi; chronic pancreatitis; endoscopic retrograde cholangiopancreatography; Endoscopy; extracorporeal shockwave lithotripsy; Gallstones; Lithotripsy; Pancreatitis; Risk factors
• ISSN: 1868-6974; 1868-6982
• DOI: 10.1002/jhbp.1013

Background Endoscopic intervention combined with extracorporeal shock wave lithotripsy (ESWL) is recommended as the first line therapy for large pancreatic stones, yet both can cause adverse events. The aim of the study was to identify the risk factors for post‐procedural pancreatitis. Methods Consecutive patients with chronic pancreatitis and pancreatic stones treated with both ESWL and subsequent endoscopic retrograde cholangiopancreatography (ERCP) from October 2016 to December 2019 were prospectively enrolled. Multivariate logistic analyses were performed to detect risk factors for post‐ESWL and post‐ERCP pancreatitis (PEP). Results A total of 714 patients (507 males, 45.60 ± 12.52 years) were included in this study. A total of 80 patients (11.2%) developed post‐ESWL pancreatitis,while 33 patients (4.6%) suffered from PEP. Steatorrhea (P = .018), multiple stones (P = .043), and stones located at the head combined with the body or tail of the pancreas (P = .015) were identified as independent protective factors for post‐ESWL pancreatitis. The history of acute exacerbations (P = .013), post‐ESWL pancreatitis (P