Contrast-enhanced ultrasound in pediatric echocardiography

The safety and benefits of cardiac contrast-enhanced ultrasound (CEUS) have been demonstrated in children and adolescents for a variety of clinical indications, including congenital heart disease. Cardiac CEUS is performed with US and the intravenous administration of ultrasound contrast agents (UCA...

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Bibliographic Details
Published in:Pediatric radiology 2021-11, Vol.51 (12), p.2408-2417
Main Authors: Kutty, Shelby, Biko, David M., Goldberg, Alan B., Quartermain, Michael D., Feinstein, Steven B.
Format: Article
Language:English
Subjects:
Adolescents
Cardiovascular disease
Children
Congenital diseases
Contrast agents
Contrast media
Contrast-enhanced ultrasound (CEUS) in children
Coronary artery disease
Echocardiography
Heart diseases
Imaging
Intravenous administration
Ischemia
Medicine
Medicine & Public Health
Neuroradiology
Nuclear Medicine
Oncology
Pediatrics
Radiology
Regulatory agencies
Safety
Ultrasonic imaging
Ultrasound
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Summary:The safety and benefits of cardiac contrast-enhanced ultrasound (CEUS) have been demonstrated in children and adolescents for a variety of clinical indications, including congenital heart disease. Cardiac CEUS is performed with US and the intravenous administration of ultrasound contrast agents (UCAs). It improves transthoracic echocardiography, which can be challenging in children and adults with acoustic window limitations (e.g., from obesity) and alterations in chest wall and cardiac geometry (e.g., from prior surgical procedures). Cardiac CEUS is also used to evaluate ischemia in the follow-up of congenital and acquired heart disease. In 2019, the United States Food and Drug Administration (FDA) approved a UCA for pediatric echocardiography. This article focuses on the clinical applications of UCAs in pediatric and adult echocardiography, outlining its diagnostic value, safety and potential for future applications.
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-021-05119-3