Lateral depletion effect on two-dimensional ordering of bacteriorhodopsins in a lipid bilayer: A theoretical study based on a binary hard-disk model

The 2D ordering of bacteriorhodopsins in a lipid bilayer was studied using a binary hard-disk model. The phase diagrams were calculated taking into account the lateral depletion effects. The critical concentrations of the protein ordering for monomers and trimers were obtained from the phase diagram...

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Bibliographic Details
Published in:The Journal of chemical physics 2021-05, Vol.154 (20), p.204904-204904
Main Authors: Suda, Keiju, Suematsu, Ayumi, Akiyama, Ryo
Format: Article
Language:English
Subjects:
Depletion
Lipids
Phase diagrams
Proteins
Trimers
Two dimensional models
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Summary:The 2D ordering of bacteriorhodopsins in a lipid bilayer was studied using a binary hard-disk model. The phase diagrams were calculated taking into account the lateral depletion effects. The critical concentrations of the protein ordering for monomers and trimers were obtained from the phase diagrams. The critical concentration ratio agreed well with the experiment when the repulsive core interaction between the depletants, namely, lipids, was taken into account. The results suggest that the depletion effect plays an important role in the association behaviors of transmembrane proteins.
ISSN:0021-9606
1089-7690
DOI:10.1063/5.0044399