The Efficacy of Acetominophen for Total Laparoscopic Hysterectomy

Despite limited data, acetaminophen, along with other agents, is commonly included in enhanced recovery after surgery (ERAS) protocols following laparoscopic hysterectomy. We aimed to systematically review the efficacy of acetaminophen on the management of postoperative pain after laparoscopic hyste...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Society of Laparoendoscopic Surgeons 2021-04, Vol.25 (2)
Main Authors: Marchand, Greg J, Azadi, Ali, Sainz, Katelyn, Masoud, Ahmed, Anderson, Sienna, Ruther, Stacy, Ware, Kelly, Hopewell, Sophia, Brazil, Giovanna, King, Alexa, Vallejo, Jannelle, Cieminski, Kaitlynne, Galitsky, Anthony, Osipov, Robert, Steele, Allison, Love, Jennifer
Format: Article
Language:English
Subjects:
Acetaminophen - therapeutic use
Analgesics, Non-Narcotic - therapeutic use
Enhanced Recovery After Surgery
Female
Humans
Hysterectomy - adverse effects
Hysterectomy - methods
Laparoscopy - adverse effects
Laparoscopy - methods
Pain Management - methods
Pain Measurement
Pain, Postoperative - drug therapy
Pain, Postoperative - etiology
Treatment Outcome
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite limited data, acetaminophen, along with other agents, is commonly included in enhanced recovery after surgery (ERAS) protocols following laparoscopic hysterectomy. We aimed to systematically review the efficacy of acetaminophen on the management of postoperative pain after laparoscopic hysterectomy. We searched PubMed, SCOPUS, Web of Science, and Cochrane Library databases for relevant clinical trials investigating the role of acetaminophen in the management of pain after laparoscopic hysterectomy. We performed the risk of bias according to Cochrane's risk of bias tool. We performed the analysis of homogeneous data under the fixed-effects model during the analysis of heterogeneous data under the random-effects model. The primary outcome was the assessment of pain score after 2, 6, 12, and 24 h. A total of 495 patients in 13 trials were included in our meta-analysis. Acetaminophen was not superior at reducing postoperative pain scores. Further analysis at progressive temporal points revealed no further significance; effect size at after 2 h (SMD = -0.020, 95% CI (-0.216; 0.176)), 6 h (SMD = -0.115, 95% CI (-0.312; 0.083)), 12 h (SMD = -0.126, 95% CI (-0.277; 0.025)), or 24 h (SMD = 0.063, 95% CI (-0.065; 0.191)). Pooled analysis was heterogeneous (  
ISSN:1938-3797
DOI:10.4293/JSLS.2020.00104