C-Reactive protein and SOFA scale: A simple score as early predictor of critical care requirement in patients with COVID-19 pneumonia in Spain

• Published in: Revista española de anestesiología y reanimación 2021-11, Vol.68 (9), p.513-522
• Main Authors: Vaquero-Roncero, L M, Sánchez-Barrado, E, Escobar-Macias, D, Arribas-Pérez, P, González de Castro, R, González-Porras, J R, Sánchez-Hernandez, M V
• Format: Article
• Language: eng ; spa
• ISSN: 2340-3284; 2341-1929
• DOI: 10.1016/j.redar.2020.11.014

To identify potential markers at admission predicting the need for critical care in patients with COVID-19 pneumonia. An approved, observational, retrospective study was conducted between March 15 to April 15, 2020. 150 adult patients aged less than 75 with Charlson comorbidity index ≤ 6 diagnosed with COVID-19 pneumonia were included. Seventy-five patients were randomly selected from those admitted to the critical care units (critical care group [CG]) and seventy-five hospitalized patients who did not require critical care (non-critical care group [nCG]) represent the control group. One additional cohort of hospitalized patients with COVID-19 were used to validate the score. Multivariable regression showed increasing odds of in-hospital critical care associated with increased C-reactive protein (CRP) (odds ratio 1.052 [1.009-1.101];  = .0043) and higher Sequential Organ Failure Assessment (SOFA) score (1.968 [1.389-2.590];