Effects of fasting on skeletal muscles and body fat of adult and old C57BL/6J mice

Fasting improves metabolic health, but is also associated with loss of lean body mass. We investigated if old mice are less resistant to fasting-induce muscle wasting than adult mice. We compared changes in skeletal muscles and fat distribution in C57BL/6J mice subjected to 48-hour fasting at adult...

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Bibliographic Details
Published in:Experimental gerontology 2021-09, Vol.152, p.111474-111474, Article 111474
Main Authors: Kvedaras, Mindaugas, Minderis, Petras, Cesanelli, Leonardo, Cekanauskaite, Agne, Ratkevicius, Aivaras
Format: Article
Language:English
Subjects:
Ageing
Fasting
Glucose tolerance
Muscle atrophy
Skeletal muscle
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Summary:Fasting improves metabolic health, but is also associated with loss of lean body mass. We investigated if old mice are less resistant to fasting-induce muscle wasting than adult mice. We compared changes in skeletal muscles and fat distribution in C57BL/6J mice subjected to 48-hour fasting at adult (6-month old) or old (24-month old) age. Old mice lost less weight (11.9 ± 1.5 vs 16.9 ± 2.8%, p 
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2021.111474