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Recurrence and colon cancer‐specific death in patients with large bowel obstruction requiring urgent operation: a competing risks analysis
Aim Clinical presentation with large bowel obstruction has been proposed as a predictor of poor long‐term oncological outcomes after resection for colorectal cancer. This study examines the association between obstruction and recurrence and cancer‐specific death after resection for colon cancer. Met...
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Published in: | Colorectal disease 2021-10, Vol.23 (10), p.2604-2618 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Aim
Clinical presentation with large bowel obstruction has been proposed as a predictor of poor long‐term oncological outcomes after resection for colorectal cancer. This study examines the association between obstruction and recurrence and cancer‐specific death after resection for colon cancer.
Method
Consecutive patients who underwent resection for colon cancer between 1995 and 2014 were drawn from a prospectively recorded hospital database with all surviving patients followed for at least 5 years. The outcomes of tumour recurrence and colon cancer‐specific death were assessed by competing risks multivariable techniques with adjustment for potential clinical and pathological confounding variables.
Results
Recurrence occurred in 271 of 1485 patients who had a potentially curative resection. In bivariate analysis, obstruction was significantly associated with recurrence [hazard ratio (HR) 2.23, CI 1.52–3.26, p |
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ISSN: | 1462-8910 1463-1318 |
DOI: | 10.1111/codi.15807 |