1,8-naphthyridine derivatives: an updated review on recent advancements of their myriad biological activities

Among all nitrogen-containing heterocycles, the 1,8-naphthyridine scaffold has recently gained an immense amount of curiosity from numerous researchers across fields of medicinal chemistry and drug discovery. This new attention can be ascribed to its versatility of synthesis, its reactiveness and th...

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Bibliographic Details
Published in:Future medicinal chemistry 2021-09, Vol.13 (18), p.1591-1618
Main Authors: Mithula, Shivani, Nandikolla, Adinarayana, Murugesan, Sankaranarayanan, Kondapalli, Venkata Gcs
Format: Article
Language:English
Subjects:
1,8-naphthyridine
analgesic
Animals
anthelmintic
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
anti-inflammatory
anticancer
antidepressant
Antidepressive Agents - chemistry
Antidepressive Agents - pharmacology
antimicrobial
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antioxidant
Antioxidants - chemistry
Antioxidants - pharmacology
antitubercular
antitumor
antiviral
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Drug Discovery
Enoxacin - chemistry
Humans
immunomodulatory
Isomerism
Molecular Structure
Nalidixic Acid - chemistry
Naphthyridines - chemistry
Naphthyridines - pharmacology
neurodegenerative
Neurodegenerative Diseases - drug therapy
Structure-Activity Relationship
Thiazoles - chemistry
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Summary:Among all nitrogen-containing heterocycles, the 1,8-naphthyridine scaffold has recently gained an immense amount of curiosity from numerous researchers across fields of medicinal chemistry and drug discovery. This new attention can be ascribed to its versatility of synthesis, its reactiveness and the variety of biological activities it has exhibited. Over the past half-decade, numerous diverse biological evaluations have been conducted on 1,8-naphthyridine and its derivatives in a quest to unravel novel pharmacological facets to this scaffold. Its potency to treat neurodegenerative and immunomodulatory disorders, along with its anti-HIV, antidepressant and antioxidant properties, has enticed researchers to look beyond its broad-spectrum activities, providing further scope for exploration. This review is a consolidated update of previous works on 1,8-naphthyridines and their analogs, focusing on the past 5 years.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2021-0086