Synthesis of POMOFs with 8-fold helix and its composite with carboxyl functionalized SWCNTs for the voltammetric determination of dopamine

Although many satisfactory studies have been developed for biomolecule detection, the complexity of biofluids still poses a major challenge to improve the performance of nanomaterials as electrochemical sensors. Herein, unprecedented polyoxometalate-based metal-organic frameworks (POMOFs) with 8-fol...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2021-09, Vol.413 (21), p.5309-5320
Main Authors: Zhou, Kunfeng, Han, Hong, Sha, Jingquan, Luan, Shaozheng, Diao, Yan, Dong, Chunyao, Yang, Jinghua
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Biochemistry
Biomolecules
Characterization and Evaluation of Materials
Chemical sensors
Chemical synthesis
Chemistry
Chemistry and Materials Science
Composite materials
Dopamine
Electric properties
Electrochemistry
Electron microscopy
Electrons
Food Science
Identification and classification
Laboratory Medicine
Metal-organic frameworks
Methods
Monitoring/Environmental Analysis
Nanocomposites
Nanomaterials
Nanotechnology
Nanotubes
Organometallic compounds
Polyoxometallates
Research Paper
Sensors
Single wall carbon nanotubes
Structure
Transmission electron microscopy
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Summary:Although many satisfactory studies have been developed for biomolecule detection, the complexity of biofluids still poses a major challenge to improve the performance of nanomaterials as electrochemical sensors. Herein, unprecedented polyoxometalate-based metal-organic frameworks (POMOFs) with 8-fold meso-helical feature, [Ag 5 (trz) 4 ] 2 [PMo 12 O 40 ] (PAZ), were synthesized and explored as electrochemical sensors to detect dopamine (DA). To improve the conductivity of PAZ and the binding ability with single-walled carbon nanotubes (SWCNTs), the nanocomposite of carboxyl functionalized SWCNTs (SWCNTs-COOH) with nano-PAZ (NPAZ), NPAZ@SWCNTs-COOH, was fabricated, and transmission electron microscopy (TEM) shows that NPAZ can interact stably and uniformly with SWCNTs-COOH, owing to more defect sites on the surface of SWCNTs-COOH. The electrochemical result of NPAZ@SWCNTs-COOH/GCE towards detecting DA shows that the linear range was from 0.05 to 100 μM with a detection limit (LOD) of 8.6 nM (S/N = 3). Graphical abstract A new electrochemical biosensing platform by combining 8-fold helical POMOFs with SWCNTs-COOH was developed for enhancing detection of dopamine for the first time, exhibiting the lowest detection limit to date.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-021-03504-3