Photocatalytic C–H Trifluoromethylthiolation by the Decatungstate Anion

A broadly applicable method for the trifluoromethylthiolation of methylene C­(sp3)–H, methine C­(sp3)–H, α-oxygen C­(sp3)–H, and formyl C­(sp2)–H bonds is presented using the decatungstate anion as the sole catalyst. By adjusting the substrate ratio and reaction concentration, this method was applie...

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Bibliographic Details
Published in:Organic letters 2021-08, Vol.23 (15), p.5729-5733
Main Authors: Schirmer, Tobias E, Rolka, Alessa B, Karl, Tobias A, Holzhausen, Ferdinand, König, Burkhard
Format: Article
Language:English
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Summary:A broadly applicable method for the trifluoromethylthiolation of methylene C­(sp3)–H, methine C­(sp3)–H, α-oxygen C­(sp3)–H, and formyl C­(sp2)–H bonds is presented using the decatungstate anion as the sole catalyst. By adjusting the substrate ratio and reaction concentration, this method was applied to 40 examples in good regioselectivities, including the derivatization of natural products. Furthermore, SCF3–drug analogues were synthesized by subsequent functionalization of the SCF3 products, highlighting the importance of this photocatalyzed C–H functionalization.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c01870