Colchicine in the Management of Acute and Chronic Coronary Artery Disease

Purpose of Review Inflammation is involved in the initiation, progression, and destabilization of atherosclerosis. Anti-inflammatory strategies aimed at reducing residual cardiovascular (CV) risk have gained increasing interest in addition to the traditional management of risk factors. Colchicine is...

Full description

Saved in:
Bibliographic Details
Published in:Current cardiology reports 2021-09, Vol.23 (9), p.120-120, Article 120
Main Authors: Bouabdallaoui, Nadia, Tardif, Jean-Claude
Format: Article
Language:English
Subjects:
Cardiology
Medicine
Medicine & Public Health
Pericardial Disease (L Klein and CL Jellis
Section Editors
Topical Collection on Pericardial Disease
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Review Inflammation is involved in the initiation, progression, and destabilization of atherosclerosis. Anti-inflammatory strategies aimed at reducing residual cardiovascular (CV) risk have gained increasing interest in addition to the traditional management of risk factors. Colchicine is a potent anti-inflammatory therapy that affects the inflammasome and other targets. We will herein review the most recent evidence regarding the usefulness of colchicine in patients with coronary artery disease (CAD). Recent Findings Colchicine has recently been repurposed from its traditional use to a number of CV indications. The landmark COLCOT and LoDoCo2 trials have demonstrated that long-term use of colchicine was associated with a reduced rate of CV events in both acute and chronic presentations of CAD, with an overall good safety profile. Summary Colchicine is emerging as a valuable, safe, and cost-effective therapy in addition to standard of care for the prevention of atherothrombotic events in CAD.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-021-01560-w