α‑Alkylation of Ketones with Alkenes Enabled by Photoinduced Activation of Silyl Enol Ethers in the Presence of a Small Amount of Water

Under blue-light irradiation conditions with a photocatalyst [1,2,3,5-tetrakis­(carbazol-9-yl)-4,6-dicyanobenzene], silyl enol ethers reacted with alkenes in the presence of a small amount of water to afford the α-alkylation products in good to high yields. A thiol cocatalyst was found to expand the...

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Published in:Organic letters 2021-08, Vol.23 (15), p.5693-5697
Main Authors: Hirata, Tsubasa, Ogasawara, Yoshihiro, Yamashita, Yasuhiro, Kobayashi, Shu̅
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Language:English
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cited_by cdi_FETCH-LOGICAL-a322t-acecb4abbe9a5822d84017e7d35222e90fcb1839f28ad7cee6dbfdd13a0b3ab43
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container_end_page 5697
container_issue 15
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container_title Organic letters
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creator Hirata, Tsubasa
Ogasawara, Yoshihiro
Yamashita, Yasuhiro
Kobayashi, Shu̅
description Under blue-light irradiation conditions with a photocatalyst [1,2,3,5-tetrakis­(carbazol-9-yl)-4,6-dicyanobenzene], silyl enol ethers reacted with alkenes in the presence of a small amount of water to afford the α-alkylation products in good to high yields. A thiol cocatalyst was found to expand the substrate scope of the reaction.
doi_str_mv 10.1021/acs.orglett.1c01824
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title α‑Alkylation of Ketones with Alkenes Enabled by Photoinduced Activation of Silyl Enol Ethers in the Presence of a Small Amount of Water
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