Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids

A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acid...

Full description

Saved in:
Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-07, Vol.9 (29), p.578-5784
Main Authors: Cao, Yue, Han, Shenghua, Zhang, Han, Wang, Jie, Jiang, Qiao-Yan, Zhou, Yimin, Yu, You-Jia, Wang, Jianfang, Chen, Feng, Ng, Dennis K. P
Format: Article
Language:English
Subjects:
Acids
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Bioassays
Biomarkers
Boron
Cancer
Cell surface
Cell Survival - drug effects
Cytotoxicity
Drug Screening Assays, Antitumor
Fluorescence
Gold
Gold - chemistry
Gold - pharmacology
Humans
Indoles - chemistry
Indoles - pharmacology
MCF-7 Cells
Metal Nanoparticles - chemistry
Particle Size
Photochemotherapy
Polymers - chemistry
Polymers - pharmacology
Raman spectra
Sialic acids
Sialic Acids - analysis
Spectroscopy
Spectrum Analysis, Raman
Surface Properties
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acids on the surface of cancer cells based on its dual surface-enhanced Raman scattering and fluorescence response. This biomarker can also trigger the photodynamic activity of these nanobipyramids, effectively eradicating the cancer cells mainly through apoptosis as shown by various bioassays. A novel nanoprobe based on gold nanobipyramids has been fabricated that can detect sialic acids on the surface of cancer cells with ultrahigh sensitivity and kill the cells through sialic acid-mediated photodynamic therapy.
ISSN:2050-750X
2050-7518
DOI:10.1039/d1tb01274f