Pd-Catalyzed Tandem Isomerization/Cyclization for the Synthesis of Aromatic Oxazaheterocycles and Pyrido[3,4‑b]indoles

An effient tandem process consisting of palladium-catalyzed double-bond isomerization of long-chain olefins and subsequent intramolecular cyclization promoted by B2(OH)2 for the synthesis of aromatic oxazaheterocycles is disclosed. This strategy can also provide rapid access to pyrido­[3,4-b]­indole...

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Bibliographic Details
Published in:Journal of organic chemistry 2021-08, Vol.86 (15), p.10032-10042
Main Authors: Ding, Linglong, Niu, Yan-Ning, Xia, Xiao-Feng
Format: Article
Language:English
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Summary:An effient tandem process consisting of palladium-catalyzed double-bond isomerization of long-chain olefins and subsequent intramolecular cyclization promoted by B2(OH)2 for the synthesis of aromatic oxazaheterocycles is disclosed. This strategy can also provide rapid access to pyrido­[3,4-b]­indoles, trans-2-olefins, and eneamides bearing various functional groups with high regio- and stereoselectivity.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c00770