Pathogenetic mechanisms of septic cardiomyopathy

Sepsis is a serious complication after infection, whose further development may lead to multiple organ dysfunction syndrome and so on. It is an important cause of death in critically ill patients who suffered an infection. Sepsis cardiomyopathy is a common complication that exacerbates the prognosis...

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Published in:Journal of cellular physiology 2022-01, Vol.237 (1), p.49-58
Main Authors: Wang, Runze, Xu, Yuerong, Fang, Yexian, Wang, Chiyao, Xue, Yugang, Wang, Fangfang, Cheng, Jin, Ren, He, Wang, Jie, Guo, Wangang, Liu, Li, Zhang, Mingming
Format: Article
Language:English
Subjects:
autophagy
Cardiomyopathies - pathology
Cardiomyopathy
Humans
Mitochondria
Mitochondria - pathology
mitochondrial dysfunction
Mitophagy
Multiple Organ Failure
Oxidation
Oxidative stress
Pathogenesis
Patients
RNS
ROS
Sepsis
Sepsis - complications
septic cardiomyopathy
Therapeutic targets
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Summary:Sepsis is a serious complication after infection, whose further development may lead to multiple organ dysfunction syndrome and so on. It is an important cause of death in critically ill patients who suffered an infection. Sepsis cardiomyopathy is a common complication that exacerbates the prognosis of patients. At present, though the pathogenesis of sepsis cardiomyopathy is not completely clear, in‐depth study of the pathogenesis of sepsis cardiomyopathy and the discovery of its potential therapeutic targets may decrease the mortality of sepsis patients and bring clinical benefits. This article reviews mitochondrial dysfunction, mitophagy, oxidation stress, and other mechanisms in sepsis cardiomyopathy. The mechanism of septic cardiomyopathy includes mitochondrial dysfunction, autophagy, DAMP, PAMP, ER stress, and noncoding RNA. 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.30527