Thyroid hormones in persons with schizophrenia: A systematic review and meta-analysis

There is accumulating evidence that individuals with schizophrenia show altered levels of thyroid hormones. However, a qualitative and quantitative synthesis of findings in this field has not been performed so far. Therefore, we aimed to perform a systematic review and meta-analysis of studies inves...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2021-12, Vol.111, p.110402-110402, Article 110402
Main Authors: Misiak, Błażej, Stańczykiewicz, Bartłomiej, Wiśniewski, Michał, Bartoli, Francesco, Carra, Giuseppe, Cavaleri, Daniele, Samochowiec, Jerzy, Jarosz, Konrad, Rosińczuk, Joanna, Frydecka, Dorota
Format: Article
Language:English
Subjects:
Comorbidity
Datasets as Topic
Humans
Psychoneuroendocrinology
Psychotic disorders
Psychotic Disorders - blood
Schizophrenia - blood
Schizophrenia - epidemiology
Thyroid gland
Thyroid Hormones - blood
Thyroid Hormones - physiology
Thyrotropin - blood
Thyroxine - blood
Triiodothyronine - blood
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Summary:There is accumulating evidence that individuals with schizophrenia show altered levels of thyroid hormones. However, a qualitative and quantitative synthesis of findings in this field has not been performed so far. Therefore, we aimed to perform a systematic review and meta-analysis of studies investigating the levels of thyroid-stimulating hormone (TSH), free thyroxine (fT4), total thyroxine (tT4), free triiodothyronine (fT3) and total triiodothyronine (tT3) in multiple-episode schizophrenia (MES) and first-episode psychosis (FEP). Electronic databases were searched from their inception until 30th May 2020 by two independent reviewers. Random-effects meta-analyses and meta-regression analyses were performed. Altogether, 19 studies were included. Persons with FEP had significantly lower TSH levels (5 studies, g = −0.26, 95%CI: −0.47 to −0.06, p = 0.013, I2 = 21.3%), higher fT4 levels (3 studies, g = 0.58, 95%CI: 0.15–1.01, p = 0.008, I2 = 64.6%) and lower tT3 levels (2 studies, g = −0.60, 95%CI: −0.82 to −0.37, p 
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2021.110402