Residual Inflammatory Risk Predicts Poor Prognosis in Acute Ischemic Stroke or Transient Ischemic Attack Patients

• Published in: Stroke (1970) 2021-09, Vol.52 (9), p.2827-2836
• Main Authors: Li, Jiejie, Pan, Yuesong, Xu, Jie, Li, Shiyu, Wang, Mengxing, Quan, Kehua, Meng, Xia, Li, Hao, Lin, Jinxi, Wang, Yilong, Zhao, Xingquan, Liu, Liping, Wang, Yongjun
• Format: Article
• Language: English
• Subjects: Aged; Biomarkers - analysis; Brain Ischemia - complications; Brain Ischemia - diagnosis; C-Reactive Protein - metabolism; Cohort Studies; Female; Humans; Inflammation - complications; Ischemic Attack, Transient - complications; Ischemic Attack, Transient - diagnosis; Ischemic Stroke - complications; Ischemic Stroke - diagnosis; Male; Middle Aged; Platelet Aggregation Inhibitors - pharmacology; Risk Factors; Stroke - complications; Stroke - diagnosis; Stroke - etiology
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.120.033152

It is still unclear whether the residual cholesterol and inflammatory risk in the acute phase is associated with prognosis of stroke. We aimed to investigate the proportion and relative contribution of residual cholesterol and inflammatory risk, determined by baseline low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hsCRP) levels, to the risk of recurrent stroke and poor functional outcome at 1 year. In this prospective multicenter cohort study, 10 499 consecutive acute ischemic stroke and transient ischemic attack patients with levels of LDL-C and hsCRP were enrolled. Patients were divided into 4 groups: residual cholesterol risk only (LDL-C ≥2.6 mmol/L and hsCRP