Inhibition of Stearoyl-CoA Desaturase by Sterculic Oil Reduces Proliferation and Induces Apoptosis in Prostate Cancer Cell Lines

Prostate cancer (PCa) is a common type of cancer affecting male population. PCa treatments have side effects and are temporarily effective, so new therapeutic options are being investigated. Due to the high demand of energy for cell proliferation, an increase in the expression and activity of lipoge...

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Bibliographic Details
Published in:Nutrition and cancer 2022, Vol.ahead-of-print (ahead-of-print), p.1-14
Main Authors: Contreras-López, Eric Francisco, Cruz-Hernández, Carlos David, Cortés-Ramírez, Sergio Alberto, Ramírez-Higuera, Abril, Peña-Montes, Carolina, Rodríguez-Dorantes, Mauricio, Oliart-Ros, Rosa María
Format: Article
Language:English
Subjects:
Apoptosis
Cell cycle
Cell Line
Cell Proliferation
Cell viability
Chemotherapy
Desaturase
Enzymatic activity
Gene expression
Humans
Male
Oils & fats
Prostate cancer
Prostatic Neoplasms - drug therapy
Protein expression
Proteins
Side effects
Stearoyl-CoA desaturase
Stearoyl-CoA Desaturase - genetics
Stearoyl-CoA Desaturase - metabolism
Tumor cell lines
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Summary:Prostate cancer (PCa) is a common type of cancer affecting male population. PCa treatments have side effects and are temporarily effective, so new therapeutic options are being investigated. Due to the high demand of energy for cell proliferation, an increase in the expression and activity of lipogenic enzymes such as the stearoyl-CoA desaturase (SCD) have been observed in PCa. Sterculic acid, contained in the seed's oil of Malvales, is a natural inhibitor of SCD. The objective of our investigation was to evaluate the effects of sterculic oil (SO) from Sterculia apetala seeds on proliferation, cell cycle and apoptosis in prostate cancer cells. SO was administered to PC3 and LNCaP cells, and to prostate normal cells; cell viability, cell cycle, apoptosis, SCD gene and protein expression and enzymatic activity were analyzed. SO administration (4 mM sterculic acid) diminished cell viability in LNCaP and PC3 cells, arrested cell cycle in G2 and promoted apoptosis. SO diminished SCD enzymatic activity with no effects on gene nor protein expression. Our results suggest that SO might offer benefits as an adjuvant in hormonal and chemotherapy prostate cancer treatments. This is the first study to analyze the effect of SO on cancer cells.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2021.1952442