Calcium signaling in cancer progression and therapy

The old Greek aphorism ‘Panta Rhei’ (‘everything flows’) is true for all living things in general. As a dynamic process, calcium signaling plays fundamental roles in cellular activities under both normal and pathological conditions, with recent researches uncovering its involvement in cell prolifera...

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Bibliographic Details
Published in:The FEBS journal 2021-11, Vol.288 (21), p.6187-6205
Main Authors: Wu, Ling, Lian, Weidong, Zhao, Liang
Format: Article
Language:English
Subjects:
Calcium
calcium ion
calcium signaling
Calcium signalling
Cancer
Cell migration
Cell proliferation
Cell survival
Gene expression
immune checkpoint
immune evasion
Immunotherapy
Signaling
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Summary:The old Greek aphorism ‘Panta Rhei’ (‘everything flows’) is true for all living things in general. As a dynamic process, calcium signaling plays fundamental roles in cellular activities under both normal and pathological conditions, with recent researches uncovering its involvement in cell proliferation, migration, survival, gene expression, and more. The major question we address here is how calcium signaling affects cancer progression and whether it could be targeted to combine with classic chemotherapeutics or emerging immunotherapies to improve their efficacy. Calcium signaling is broadly involved in cancer progression as its abnormal activation promotes malignant behaviors of cancer cells, contributes to various oncogenes and oncogenic pathways, and mediates suppression of immune response. Therefore, targeting calcium signaling is potential for the development of novel anticancer therapies. A calcium signaling‐based agent may be a cancer cell killer, a chemo‐sensitizer and an immunotherapy enhancer.
ISSN:1742-464X
1742-4658
DOI:10.1111/febs.16133