Anti-Inflammatory and Antinociceptive Properties of Kielmeyerone A, a Chromenone Isolated from the Roots of Kielmeyera reticulata

Four new chromenones, kielmeyerones A-D ( - ), were obtained from the roots of . Their structures were elucidated based on spectroscopic data (NMR and HRESIMS) interpretation. The pharmacological activity of kielmeyerone A ( ), the major compound, was evaluated using in vitro and in vivo inflammatio...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2021-08, Vol.84 (8), p.2157-2164
Main Authors: Boness, Heiter V M, de Oliveira, Milena S, Batista, Carine S C, Almeida, Leticia S, Boffo, Elisangela F, Villarreal, Cristiane F, Cruz, Frederico G
Format: Article
Language:English
Subjects:
Analgesics - isolation & purification
Analgesics - pharmacology
Animals
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Brazil
Cell Line
Edema - chemically induced
Edema - drug therapy
Inflammation - chemically induced
Inflammation - drug therapy
Macrophages - drug effects
Magnoliopsida - chemistry
Male
Mice
Molecular Structure
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Plant Roots - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Four new chromenones, kielmeyerones A-D ( - ), were obtained from the roots of . Their structures were elucidated based on spectroscopic data (NMR and HRESIMS) interpretation. The pharmacological activity of kielmeyerone A ( ), the major compound, was evaluated using in vitro and in vivo inflammation and pain models. During in vitro screening, , at noncytotoxic concentrations (0.097-1.56 μM), inhibited NO production by J774 macrophages stimulated with LPS and IFN-γ. In the complete Freund's adjuvant-induced inflammation model in mice, (12.5-50 mg/kg) inhibited paw edema, demonstrating an anti-inflammatory effect. Additionally, (12.5-50 mg/kg) induced a dose-dependent antinociceptive effect in the late phase of the formalin test, a profile similar to those of nonsteroidal anti-inflammatory drugs. Mice treated with (100 mg/kg) did not show motor performance alterations using a rota-rod test. Thus, the present study has characterized new chromenones from and has provided evidence of the anti-inflammatory and antinociceptive properties of one of these, kielmeyerone A ( ).
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.1c00157