Review of coagulation preanalytical variables with update on the effect of direct oral anticoagulants

There are many preanalytical variables (PAV) that are known to affect coagulation testing. The more commonly acknowledged PAV addressed by the clinical laboratory tend to start with their influence on blood collection, but realistically coagulation PAV starts with the patient, where the laboratory h...

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Bibliographic Details
Published in:International journal of laboratory hematology 2021-07, Vol.43 (S1), p.109-116
Main Author: Gosselin, Robert C.
Format: Article
Language:English
Subjects:
Anticoagulants
Blood coagulation
coagulation testing
direct oral anticoagulants
Laboratories
laboratory practice
Patients
preanalytical variables
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Summary:There are many preanalytical variables (PAV) that are known to affect coagulation testing. The more commonly acknowledged PAV addressed by the clinical laboratory tend to start with their influence on blood collection, but realistically coagulation PAV starts with the patient, where the laboratory has less influence or control. Patient selection and appropriate timing for blood collection may be integral for assuring proper diagnosis and management. Laboratory control and assurance for ideal phlebotomy practice would mitigate most PAVs related to blood collection to minimize suboptimal sample collection. Laboratory oversight of sample transportation, processing and storage will assure sample integrity until testing can be facilitated. The purpose of this document is to review common PAV that should be taken into consideration when ordering, performing and interpreting a coagulation test result, with additional attention to the effect of direct oral anticoagulants (DOACs).
ISSN:1751-5521
1751-553X
DOI:10.1111/ijlh.13585