Synthesis of natural products containing highly strained trans -fused bicyclo[3.3.0]octane: historical overview and future prospects

Owing to high strain energy, molecules with trans -fused bicyclo[3.3.0]octane ring systems are very difficult to synthesize, and there are very few approaches to access them. Recently, a number of natural products with such ring systems have been made by the synthetic community. However, there has b...

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Bibliographic Details
Published in:Chemical Society reviews 2021-09, Vol.50 (17), p.9430-9442
Main Authors: Zhang, Wen, Li, Lingzi, Li, Chuang-Chuang
Format: Article
Language:English
Subjects:
Literature reviews
Natural products
Octanes
Synthesis
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Summary:Owing to high strain energy, molecules with trans -fused bicyclo[3.3.0]octane ring systems are very difficult to synthesize, and there are very few approaches to access them. Recently, a number of natural products with such ring systems have been made by the synthetic community. However, there has been no review in this field before. This review provides a systematic and comprehensive discussion on the synthesis of natural products containing trans -fused bicyclo[3.3.0]octanes and the historical context of this work. The prospects for future research in this field are also discussed. Covering the literature before 2021, this review aims to offer a helpful reference for total synthesis of highly strained natural products containing trans -fused bicyclo[3.3.0]octane ring systems.
ISSN:0306-0012
1460-4744
DOI:10.1039/d0cs01471k