Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a π‑Acceptor Biphosphoramidite Ligand

The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)­enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylal...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2021-08, Vol.23 (15), p.6067-6072
Main Authors: Zhao, Jiangui, Zheng, Xueli, Tao, Shaokun, Zhu, Yuxin, Yi, Jiwei, Tang, Songbai, Li, Ruixiang, Chen, Hua, Fu, Haiyan, Yuan, Maolin
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)­enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important E-(poly)­enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02140