Risk factors for new-onset bipolar disorder in a community cohort: A five-year follow up study

•Depressive disorder was the strongest risk factor to new-onset BD in community sample of young adults.•Substance abuse/dependence is another risk factor for BD in young adults.•The early detection of BD depends on improving the mental health diagnosis. The aim of this study was to assess the risk f...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research 2021-09, Vol.303, p.114109-114109, Article 114109
Main Authors: Bach, Suelen de Lima, Cardoso, Taiane de Azevedo, Moreira, Fernanda Pedrotti, Mondin, Thaíse Campos, Simjanoski, Mario, Kapczinski, Flávio Pereira, Frey, Benicio N., Souza, Luciano Dias de Mattos, da Silva, Ricardo Azevedo, Jansen, Karen
Format: Article
Language:English
Subjects:
Cohort studies
Community sample
Epidemiology
Mental health
Young adults
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Depressive disorder was the strongest risk factor to new-onset BD in community sample of young adults.•Substance abuse/dependence is another risk factor for BD in young adults.•The early detection of BD depends on improving the mental health diagnosis. The aim of this study was to assess the risk factors for new-onset Bipolar Disorder (BD) in a community sample of young adults. This is a prospective cohort study including a population-based sample of young adults aged between 18-24 years. The baseline took place from 2007 to 2009, and 1560 subjects were included. Five years after, 1244 individuals were re-evaluated (79.7% retention). Substance abuse/dependence was assessed using the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), and mental disorders were assessed using the Mini International Neuropsychiatric Interview 5.0 (MINI) at both waves. The cumulative incidence of BD in five years was 4.6%. There was no significant association between sociodemographic factors and BD incidence. Tobacco, cannabis, cocaine/crack, other substances abuse/dependence increased the relative risk for BD. Depressive, anxiety, post-traumatic stress disorders, and the suicide risk increased the relative risk to BD. Depressive episode was the strongest risk factor for BD, followed by other mental disorders and substance abuse/dependence in a probabilistic community sample of young adults. Preventive actions in mental health directed at the non-clinical population are needed for early detection and better management of BD.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2021.114109